Natural products have been used since ancient times to treat illnesses and terrestrial organisms have been studied extensively from a chemical point of view. Marine organisms, on the other hand are definitely understudied ...

The aim of this instigation was to develop thermoresponsive polymer films for cell culture use. Conventional cell detachment methods involve the use of proteolytic enzymes, such as trypsin, or mechanical scrapping. These ...

One promising direction of regenerative medicine is the development of cell sheet-based tissue-like constructs. The cell sheets preserve ECM and cell−cell junctions. This may greatly support cell adherence to damaged organ ...

Natural products have been perceived as privileged structures in drug discovery based on their evolutionary experience. Chapter 1, explores previous exploitation of this platform by medicinal chemists to identify some ...

The objective of this thesis is to set up new diagnostic methods for the study of asthma and related respiratory conditions in an Irish clinical laboratory, and to deepen our knowledge of the pathophysiology of this illness. ...

An attractive, yet challenging approach to overcome poor water solubility is to convert a crystalline Active Pharmaceutical Ingredient (API) into its more soluble amorphous form.1-3 Nevertheless, the use of amorphous drug ...

Marine organisms are prolific producers of novel and structurally interesting metabolites. The identification of marine natural products contributes to many scientific areas including pharmacology, chemical ecology, chemical ...

The application of thin polymeric films for medical purposes is growing very fast. Two of the most important uses of thin polymer films are drug coatings for controlled release and tissue engineering. Thermoresponsive ...

The primary objective of the work presented in this Thesis is to investigate the oxidation chemistry of unsaturated hydrocarbons. Butenes (1-, 2-, iso-butene) and 1,3-butadiene are the shortest olefins with structural ...

The stereoselective generation of 1,2-cis linkages continues to be a substantial challenge in carbohydrate chemistry today. Lewis acid-promoted anomerisation of 1,2-trans linkages offers a facile method to generate 1,2-cis ...