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Now showing items 21-29 of 29
Exploring the potential of glycogen synthase kinase-3 (GSK3) mediated therapy in castrate-resistant prostate cancer
(2016-11-30)
Glycogen Synthase Kinase 3 (GSK3) is involved in a myriad of signalling pathways and has recently received considerable interest due to its conflicting roles tumourigenesis. Though it has classically been regarded as a ...
Characterisation of the molecular and functional changes exerted on human bone marrow mesenchymal stem cells by prostate cancer cells
(2016-07-01)
Mesenchymal stem cells (MSCs) are a heterogenous population of multipotent cells
that are capable of differentiating into osteocytes, chondrocytes and adipocytes.
MSCs reside in various areas such as the bone marrow, ...
The design, manufacture and testing of a composite polysialic acid mimetic peptide loaded collagen nerve graft for use in peripheral nerve repair
(NUI Galway, 2016-02-15)
Peripheral nerve injuries can be debilitating for patients. The current gold-standard technique for peripheral nerve repair is autograft. This procedure involves harvesting a non-critical nerve from a donor site from the ...
USP9X controls DNA replication fork stability and the replication stress checkpoint through Claspin
(2016-02-05)
Cells possess checkpoint pathways which are important for maintaining genome stability and preventing cancer. These signalling pathways include the ATR and CHK1 kinases which are activated in response to DNA damage or ...
In vitro, pre-clinical and commercial evaluation of a novel xeno- and serum-free culture system for production of human bone marrow derived mesenchymal stem cells for bone regeneration
(2016-10-21)
The therapeutic potential of mesenchymal stem cells (MSCs) is recognised in treating a wide range of debilitating diseases. For clinical-scale manufacturing, serum-free and xenogenic-free media formulations have been ...
Immunogenicity of allogeneic mesenchymal stem cells
(2016-10-20)
Allogeneic mesenchymal stem cells (allo-MSC) are a promising “off-the-shelf” therapy and are often cited as failing to elicit anti-donor immune responses. Intra-muscular (IM) administration may be the optimal route for ...
Neuroanatomical dysconnectivity in bipolar disorder
(2016-10-13)
Bipolar Disorder (BD) is a major psychotic illness characterized by cyclic mood dysregulation. The dysconnectivity hypothesis suggests that psychotic illnesses arise not from regionally specific focal pathophysiology, but ...
Human endogenous retrovirus K (HERV-K) in prostate cancer
(2016-08-08)
Millions of years of infection by viral agents have left their mark on the human genome in the form of human endogenous retroviruses (HERVs). These retroelements integrated into our germline, became subject to Mendelian ...
Evaluating conversation partner programmes: perspectives of people with aphasia
(2016-06-22)
Background
Stroke is the most common cause of disability in the western World. Approximately 176,000 new individuals in the United Kingdom and Ireland are diagnosed with stroke annually with up to one third experiencing ...