Now showing items 21-25 of 25
Immunomodulation in mesenchymal stem cell therapy for osteoarthritis: mechanistic insights on the role of cell death and engraftment
(NUI Galway, 2018-11-02)
Osteoarthritis (OA) is a degenerative pathology of the articular cartilage causing chronic pain and disability in millions of individuals. In OA synovia, resident macrophages and infiltrated lymphocytes contribute to the ...
Regulation of cell fate by microRNAs during unfolded protein response and its role in cancer
(NUI Galway, 2018-12-20)
The endoplasmic reticulum (EnR) stress is a common phenomenon in various cancers such as breast, colorectal, skin and hepatocellular carcinoma. Several pathophysiological events (e.g., radiation, aneuploidy, oncogenic ...
Optimisation and characterisation of cholecyst-derived extracellular matrix for abdominal wall reconstruction
(NUI Galway, 2018-10-19)
Polypropylene mesh was created by Usher in 1962 after he experienced unsatisfactory results from using autografts and allografts for hernia repairs. More than fifty years later, polypropylene is still the most popular ...
Stem cell modelling for the role of NRXN1 deletion in Autism Spectrum Disorder
(NUI Galway, 2018-12-21)
Autism spectrum disorder (ASD), a multi-factorial disease, often has co-morbidity with epilepsy, which is associated with excessive neuronal firing. The pre-synaptic protein Neurexin1 (NRXN1) signals bi-directionally through ...
Metastatic breast cancer: Patterns of metastasis and novel biomarkers
(NUI Galway, 2018-05-25)
Breast cancer is a heterogeneous disease and is the leading cause of cancer-related deaths among women, with metastatic disease the principle cause of mortality. In recent years great advances have been made in stratifying ...