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Now showing items 11-16 of 16
The design, manufacture and testing of a composite polysialic acid mimetic peptide loaded collagen nerve graft for use in peripheral nerve repair
(NUI Galway, 2016-02-15)
Peripheral nerve injuries can be debilitating for patients. The current gold-standard technique for peripheral nerve repair is autograft. This procedure involves harvesting a non-critical nerve from a donor site from the ...
Metastatic breast cancer: Patterns of metastasis and novel biomarkers
(NUI Galway, 2018-05-25)
Breast cancer is a heterogeneous disease and is the leading cause of cancer-related deaths among women, with metastatic disease the principle cause of mortality. In recent years great advances have been made in stratifying ...
Factors influencing diagnosis and outcome in HER2 receptor positive breast cancer
(NUI Galway, 2019-02-22)
Introduction
About 30% of breast cancers are HER2 receptor positive, these breast cancers traditionally had a poor prognosis but the introduction of targeted anti-HER2 therapy (Trastuzumab) has resulted in a vast improvement ...
Optimisation and characterisation of cholecyst-derived extracellular matrix for abdominal wall reconstruction
(NUI Galway, 2018-10-19)
Polypropylene mesh was created by Usher in 1962 after he experienced unsatisfactory
results from using autografts and allografts for hernia repairs. More than fifty years later,
polypropylene is still the most popular ...
Mastectomy and breast reconstruction in the modern era: the role of neoadjuvant therapies and regenerative surgery
(NUI Galway, 2018-10-09)
Complete surgical resection with disease free margins remains the cornerstone of effective breast cancer treatment. Breast cancer management continues to evolve with the development of more sophisticated techniques of ...
Effects of remote ischaemic preconditioning on vascular and general surgery patients’ outcomes
(NUI Galway, 2017-09-29)
Remote ischaemic preconditioning (RIPC) has been suggested as a non-invasive treatment option in many recent studies. The focus of this thesis is to evaluate the possible effect of this on major health problems in vascular ...