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Now showing items 11-19 of 19
The multi-spectral signal properties of multiple reference optical coherence tomography
(NUI Galway, 2019-07-05)
Efforts to reduce the size and costs of optical coherence tomography systems (OCT) for consumer
applications, in general, focus on Fourier-domain OCT, due to its potential to be integrated on an optical chip, implementing ...
The life-cycle of methanogenic granular biofilms
(NUI Galway, 2019-08-19)
Anaerobic granules, sometimes referred to as methanogenic granules, underpin the sustainable treatment of wastewater in high-rate anaerobic bioreactors. They are spontaneously-forming self-immobilised biofilm aggregates ...
Characterisation of three zinc finger proteins ZC3H8, ZC3H11A and ZC3H14, identified as new partners of ATM, the central regulator of biological response to DNA double strand breaks
(NUI Galway, 2019-12-16)
The integrity of our genome is very important therefore, our cells have developed efficient DNA
repair mechanisms to control this integrity and avoid mutations. Although the DNA double
strand break response pathway is ...
Study of silyl protecting groups in anomerisation reactions: Total synthesis of a glycolipid from Plakortis simplex and its mimetics
(NUI Galway, 2019-02-04)
This thesis deals with anomerisation, which is, in other words, epimerisation at the anomeric centre, usually interpreted as being from the equatorial to the axial anomer. An objective was to enhance the knowledge of this ...
Carbohydrates in the synthesis of macrocycles and glycoclusters
(NUI Galway, 2019-01-28)
This thesis deals with efforts to generate new bioactive organic compounds. The main focus
has been on the use of carbohydrate building blocks for synthesis of both macrocyclic
compounds and glycoclusters for biological ...
Irish seagrass ecology and habitat mapping in the context of climate change
(NUI Galway, 2019-01-28)
Seagrasses play an important ecological role worldwide, providing numerous ecosystems services. Zostera marina is a dominant meadow-forming seagrass in temperate regions in the northern hemisphere, including Irish coasts. ...
Development of drugs targeting the human tRNA ligase RtcB in breast cancer
(NUI Galway, 2019-02-15)
The RNA ligase RtcB has been shown to regulate RNA function by direct exon ligation of spliced XBP1 messenger RNA cleaved by the endoplasmic reticulum (ER) stress sensor IRE1α. Ligation by RtcB leads to the expression of ...
Investigation of various ligand design approaches and synthesis of diverse heterocyclic bioactive compounds
(NUI Galway, 2019-09-27)
Structure-based design and ligand-based design are one of the most common approaches used to develop new inhibitors against druggable protein targets in various human disorders. Mcl-1 is a protein belongs to Bcl-2 family ...
Synthesis and evaluation of multivalent ligands for macrophage galactose C-type lectin. Development of new chemical tools for immunological research and structural investigation of the lectin with GalNAc and derivatives
(NUI Galway, 2019-09-30)
Synthetic chemistry can provide powerful tools to explore the correlation between an antigen’s
chemical structure and the type of immune response triggered. This thesis work has focused
on the design, synthesis and ...