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Now showing items 11-20 of 29
Invasive haemodynamic characteristics and clinical outcomes of patients presenting with symptomatic severe aortic valve stenosis undergoing transcatheter aortic valve implantation
(2016-01-12)
The present thesis is comprised of an introduction followed by eight chapters. The introduction gives an overview of the transcatheter aortic valve implantation (TAVI) procedure and details the patient selection process. ...
A prospective evaluation of involuntary admission from the viewpoint of service users
(2016-09-19)
Introduction:
Involuntary admission is often a traumatic experience for patients and it is associated with
negative attitudes which can persist after the episode of illness has abated.
Aims:
The aims of the study were ...
Hypoxia activates the PTHrP – Zfp521 – MEF2C pathway to attenuate hypertrophy in mesenchymal stem cell derived cartilage
(2016-04-22)
The treatment of cartilage defects remains an unmet medical need as the current treatment options are currently sub-optimal as the most common treatment options; microfracture and autologous chondrocyte implantation (ACI) ...
Genotype-dependent responsivity to inflammatory pain: the role of TRPV1 in the periaqueductal grey
(2016-09-21)
The ability to experience pain is essential for survival, and to prevent potential tissue damage upon exposure to noxious stimuli. The periaqueductal grey - rostral ventromedial medulla – dorsal horn of the spinal cord ...
Therapeutic applications of endothelial progenitor cells for diabetic ulcer healing
(2016-10-16)
Diabetic ulcer healing is a major problem in health care. Impaired circulation has long been associated with diabetes resulting in an increased risk of foot ulceration and making an increase in blood flow an excellent ...
Novel mechanisms for neoadjuvant chemotherapeutic response monitoring in breast cancer
(2016-11-25)
Breast cancer is the most frequently diagnosed female malignancy worldwide, causing the majority of cancer-related deaths amongst women. While the management of this disease has transformed dramatically in recent years, ...
Therapies for acute respiratory distress syndrome: determination of the mechanisms of action of hypercapnia and the therapeutic efficacy of mesenchymal stromal cells
(2016-09-20)
Rationale: Acute Respiratory Distress Syndrome (ARDS) causes severe respiratory failure and is associated with high mortality. Pharmacological therapies are non-existent and supportive ventilation treatments are limited. ...
The need for and effectiveness of an individualised therapeutic programme for people living with prolonged disorders of consciousness in non-specialist care settings in the Republic of Ireland
(2016-11-16)
Introduction: Disorders of consciousness are an increasing phenomena and people are living longer with these conditions. The care needs begin with acute medicine and ICU care and frequently end up with life-long nursing ...
Optimising the maturation rate of arteriovenous fistula (AVF) in patients with end stage renal disease (ESRD)
(2016-01-25)
A well-functioning Arteriovenous Fistula (AVF) has been shown to be the best modality for access in patients with end-stage kidney disease going for dialysis. Maturation of AVF is complex and depends on various biomechanical ...
Exosome-encapsulated microRNAs as circulating biomarkers for breast cancer
(2016-06-15)
Breast cancer is a heterogeneous group of diseases survival from which depends on stage at diagnosis. The development of blood-based biomarkers which may facilitate earlier detection and possibly subtype delineation remains ...