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The role of matrix properties and extrinsic loading in osteoblast-osteocyte differentiation in tissue engineered scaffolds
(2018-02-05)
Bone tissue engineering is a promising field with the potential to generate tissue substitutes, by taking advantage of mesenchymal stem cells ability to grow and produce tissue substitutes under specific physical conditions. ...
Towards low cost multiple reference optical coherence tomography for in vivo and NDT applications
(2016-01-21)
Developing a cost-effective, compact, and easy-to-use optical coherence tomography
(OCT) platform based on smartphones for personal care and point-of-care (POC) diagnostics
can enable rapid and accurate diagnosis with ...
Human induced pluripotent stem cells as a model for neurodevelopmental disease
(2015-10-01)
Abstract
Autism spectrum disorders (ASD) are neurodevelopmental disorders which encompass a wide range of symptoms, including intellectual disability and delayed development, while the phenotype can range from mild to ...
Thermal elevations of orthopaedic procedures: A bone cell perspective
(2014-05-27)
Thermal elevations experienced by bone during orthopaedic procedures, such as cutting and drilling, exothermal reactions from bone cement, and thermal therapies such as tumour ablation, can result in thermal damage leading ...
Analysis of the role of Rho GTPases in epithelial cells
(2014-11-19)
Rho GTPases are a family of small GTP binding proteins that function as molecular switches for the control of a variety of fundamental cellular processes, and therefore represent potentially vital proteins for skin ...
Assessing and training early emergent derived relational responding in children with autism
(2015-09-30)
Many children with autism fail to develop generative language despite intensive teaching; their language can be described as “rote”. Research in the area of derived stimulus relations, in particular Relational Frame Theory ...
Genetic determinants of disease characteristics of inflammatory bowel disease and diverticulitis
(2015-05-05)
Background: Inflammatory Bowel Disease (IBD) is a complex, multigenic disease in which both the innate and adaptive immune systems play a strong role. Although over 40 microbes including bacteria, viruses and yeasts and ...
Invasive haemodynamic characteristics and clinical outcomes of patients presenting with symptomatic severe aortic valve stenosis undergoing transcatheter aortic valve implantation
(2016-01-12)
The present thesis is comprised of an introduction followed by eight chapters. The introduction gives an overview of the transcatheter aortic valve implantation (TAVI) procedure and details the patient selection process. ...
Elastin-like polypeptide mediated proangiogenic and anti-inflammatory gene therapy for critical limb ischemia
(2014-12-17)
Critical limb ischemia is a major clinical problem. Despite rigorous treatment regimes, there has been modest success in reducing the rate of amputations in these patients. Reduced level of blood flow and enhanced inflammation ...
A qualitative exploration of ‘coming out’ in the context of a heterosexual marriage in Ireland: the perspectives of children, spouses and self
(NUI Galway, 2019-04-09)
Despite several decades of research into the sexual orientation of parents and spouses, there is a dearth of literature that explores the experience of having a parent or spouse declare a change in sexual orientation in ...