Now showing items 111-112 of 112
Implications of histone H2AX abundance in breast cancer
(NUI Galway, 2019-12-09)
Histones are responsible for the packaging of DNA into a eukaryotic cell nucleus, and the H2A variant H2AX plays an important role in the DNA damage response (DDR). The phosphorylated form of H2AX, known as γH2AX, has been ...
USP9X controls DNA replication fork stability and the replication stress checkpoint through Claspin
Cells possess checkpoint pathways which are important for maintaining genome stability and preventing cancer. These signalling pathways include the ATR and CHK1 kinases which are activated in response to DNA damage or ...