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Regulation of cell fate by microRNAs during unfolded protein response and its role in cancer
(NUI Galway, 2018-12-20)
The endoplasmic reticulum (EnR) stress is a common phenomenon in various cancers such as breast, colorectal, skin and hepatocellular carcinoma. Several pathophysiological events (e.g., radiation, aneuploidy, oncogenic ...
Human endogenous retrovirus K (HERV-K) in prostate cancer
(2016-08-08)
Millions of years of infection by viral agents have left their mark on the human genome in the form of human endogenous retroviruses (HERVs). These retroelements integrated into our germline, became subject to Mendelian ...
Paediatric rotavirus gastroenteritis - regional prevalent serotypes, correlation with disease severity, nosocomial acquisition, viral co-infection and the impact of rotavirus vaccine in one region of Ireland
(NUI Galway, 2019-09-13)
Background: Rotavirus is the primary cause of gastroenteritis in children worldwide and a leading cause of gastroenteritis in children younger than three years, with a significant burden both globally and in Ireland. ...
Effects of remote ischaemic preconditioning on vascular and general surgery patients’ outcomes
(NUI Galway, 2017-09-29)
Remote ischaemic preconditioning (RIPC) has been suggested as a non-invasive treatment option in many recent studies. The focus of this thesis is to evaluate the possible effect of this on major health problems in vascular ...
Therapeutic targets for duchenne muscular dystrophy
(NUI Galway, 2019-07-05)
Duchenne Muscular Dystrophy (DMD) is a progressive X-linked fatal muscle degenerative disorder caused by the absence of the sarcolemmal associated dystrophin-glycoprotein complex (DGC) that connects the intracellular ...
Endocannabinoid modulation of TLR3-induced neuroinflammation
(2017-10-06)
Toll-like receptors (TLRs) play a key role in the recognition and activation of the innate immune system in response to infection. However, aberrant TLR activation has been implicated in predisposing to, and exacerbating, ...
Investigation of the central serotonergic system in the olfactory bulbectomized rat model of depression
(2017-11-10)
Depression is a devastating heterogeneous disease that has a high lifetime prevalence. Despite over 50 years of research, the aetiology of depression is still largely undetermined but the improper functioning of the central ...
Evaluating conversation partner programmes: perspectives of people with aphasia
(2016-06-22)
Background
Stroke is the most common cause of disability in the western World. Approximately 176,000 new individuals in the United Kingdom and Ireland are diagnosed with stroke annually with up to one third experiencing ...
Progression of neuroanatomical abnormalities in psychosis
(NUI Galway, 2019-12-18)
Background: Structural brain changes and their cross-sectional relationships with clinical and functional measures have been demonstrated several times using magnetic resonance imaging at the onset of first-episode of ...
Regulation of fear, anxiety and cognition in the presence or absence of pain by peroxisome proliferator-activated receptors
(NUI Galway, 2019-06-07)
Fear/anxiety and pain modulate one another reciprocally, but the neurobiological mechanisms that underlie this interaction are not completely understood. Fear-conditioned analgesia (FCA) is pain suppression upon exposure ...