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Ex vivo investigation of iron handling in the brain
(2016-11-04)
Aberrant iron deposition in the brain is associated with aging and neurodegenerative disorders including multiple sclerosis, Alzheimer’s disease and Parkinson’s disease. It is unclear whether metabolic dyshomeostasis of ...
Development of transgenic and genome editing tools to study the role of Notch signalling in Hydractinia echinata
(2016)
Hydractinia is a colony forming marine invertebrate and a member of the phylum Cnidaria. Members of this genus have been models for developmental biologists for over a century and feature many characters of evolutionary ...
Development of a nested 3D hydrodynamic model for tidal turbine impact assessment
(2016-05-12)
Tidal current energy resources have the potential to provide a sizable proportion of our future energy requirements. However, significant questions still exist on the impacts of tidal turbines on the hydrodynamic environment. ...
Mindfulness and painting: the relevance of Dufrenne
(2016-05-27)
This thesis examines the relationship between painting and mindfulness, including the notion of painting as a mindfulness based intervention. This premise is explored with reference to the aesthetics of Mikel Dufrenne. ...
Neurotrophic signalling and inhibition in breast cancer and chronic lymphocytic leukaemia
(2016-01-15)
Neurotrophins are important growth factors for neuronal cells. They interact with the Trk kinase receptors and the p75NTR receptor to induce several signaling pathways. Neurotrophins and their receptors are known regulators ...
Towards low cost multiple reference optical coherence tomography for in vivo and NDT applications
(2016-01-21)
Developing a cost-effective, compact, and easy-to-use optical coherence tomography
(OCT) platform based on smartphones for personal care and point-of-care (POC) diagnostics
can enable rapid and accurate diagnosis with ...
On the table of marks of a direct product of finite groups
(2016-02-10)
The table of marks was first introduced by William Burnside in his book "Theory of groups of finite order" in
1955. The table of marks counts the number of fixed points one subgroup has in the action of the cosets of ...
Exosomal microRNAs in colorectal cancer
(2016)
Cancer cells have been shown to release a variety of extracellular membrane vesicles
including microvesicles known as exosomes. Exosomes have recently been found to
contain microRNAs (miRNAs) however the full range within ...
Synthesis of novel glycolipids and investigation into the anomerisation of selenium glycosides
(2016-07-14)
The first section of this thesis describes the synthesis of novel glycosphingolipids with an α-triazole at the anomeric carbon. Glycosphingolipids are amphiphilic molecules containing a carbohydrate head glycosidically ...
Dissecting the pan-placodal gene regulatory network reveals novel interactions driving sense organ development in vertebrates
(2016-02-17)
The genes encoding the transcription factor Six1, and its co-factor Eya1 together mark the embryonic territory - the pan-placodal ectoderm (PPE) - that gives rise to most cranial sense organs in vertebrates. Mutation of ...