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Synthesis of s-glycolipids and peptidomimetics
(2011-08-19)
Chapters one and two of this thesis describe the synthesis of two novel glycosphingolipid derivatives. Glycosphingolipids are amphiphilic molecules consisting of a carbohydrate head group glycosidically linked to a sphingoid ...
N- and O- linked Glycosylation, Developing Mass Spectrometric Strategies for the Characterisation of Glyco-epitopes
(2012-12-10)
The overall goal of this thesis was to adopt a liquid chromatography-mass spectrometry (LC-MS) platform for glycomic analysis of glycoproteins. In particular we were interested in characterizing complex glycomic samples ...
Crystal Growth Using Low Temperature Gradient Sublimation in Vacuo
(2012-09-27)
A sublimation method based on the use of a conventional vacuum oven was developed for growing high quality single crystals of organic compounds suitable for structure determination. Key features of the method are the use ...
Bioelectrochemical films on electrodes for application to biofuel cells
(2012-05-04)
This thesis focuses on studies of both enzymatic (EFC) and microbial (MFC) fuel cells. In the enzymatic fuel cell studies, interactions between enzymes, osmium based complexes and redox polymers are characterized ...
First Synthesis of an Aziridinyl Fused Pyrrolo[1,2-a]benzimidazole and Cytotoxicity Evaluation of Various Imidazobenzimidazolequinones Towards Human Normal and Cancer Cell Lines
(2011-07-13)
Chapter 1 provides a review of aziridine containing anti-tumour agents and
some key syntheses of the aziridinomitosene skeleton. A novel protocol for
aziridine ring fusion is described leading to the preparation of the ...
Open-source bioelectronics for development of electrochemical biosensors and assays
(NUI Galway, 2019-02-20)
This thesis presents steps in the development of open-source bioelectronics that gather together and combine in the demonstration of a system capable of operating a fully integrated wireless electrochemical biosensor.
Synthesis and application of chiral substituted oxazolines
(2015-09-08)
This thesis consists of two subprojects, dealing with the design, synthesis and application of novel (1) pyridinyl-oxazoline ligands and (2) prolyl-oxazoline ligands.
In Project 1 eleven novel pyridinyl-oxazoline ligands ...
Pulsatile Drug Delivery by Thermoresponsive Polymer Films with Mathematical Model and Evaluation of Thermoresponsive Properties of Block Copolymers
(2012-11-26)
In this thesis, a new controlled thermoresponsive drug delivery system based
on UV crosslinkable copolymer films was fabricated and characterised. The
characterisation of the drug loaded films has shown an even drug ...
Synthesis of S-glycolipids and peptidomimetics
(2011-08-19)
Chapters one and two of this thesis describe the synthesis of two novel glycosphingolipid derivatives. Glycosphingolipids are amphiphilic molecules consisting of a carbohydrate head group glycosidically linked to a sphingoid ...
Synthetic, Structural, Spectroscopic and Theoretical Studies on Homo- and Heterometallic Paramagnetic Complexes
(2013-01-08)
This thesis covers many areas within the field of molecular magnetism. With the exception of chapter 6, all novel complexes in this thesis have been synthesized using the bidentate ligand 2,2'-biphenol (LH2), usually in ...