Search
Now showing items 1-10 of 16
Cartilage repair in a rabbit model: Development of a novel subchondral defect and assessment of early cartilage repair using a rabbit mesenchymal stem cell seeded scaffold
(2018-02-14)
Purpose: To develop a subchondral defect in a rabbit model and assess cartilage repair using a mesenchymal stem cell-seeded scaffold.
Materials and Methods: To achieve this goal, a bovine explant model and two pilot ...
Exosomal microRNAs in colorectal cancer
(2016)
Cancer cells have been shown to release a variety of extracellular membrane vesicles
including microvesicles known as exosomes. Exosomes have recently been found to
contain microRNAs (miRNAs) however the full range within ...
Genetic determinants of disease characteristics of inflammatory bowel disease and diverticulitis
(2015-05-05)
Background: Inflammatory Bowel Disease (IBD) is a complex, multigenic disease in which both the innate and adaptive immune systems play a strong role. Although over 40 microbes including bacteria, viruses and yeasts and ...
Investigating the impact of genomic profiling on breast cancer risk prediction, treatment and outcome
(2018-02-05)
It has, for many years, been acknowledged that “breast cancer” is an umbrella term for many genetically and immunophenotypically distinct malignancies of the breast. Treatment paradigms are shifting in direct response to ...
Novel mechanisms for neoadjuvant chemotherapeutic response monitoring in breast cancer
(2016-11-25)
Breast cancer is the most frequently diagnosed female malignancy worldwide, causing the majority of cancer-related deaths amongst women. While the management of this disease has transformed dramatically in recent years, ...
microRNA-mediated intercellular communication in the primary breast tumour microenvironment
(2014-08-30)
microRNAs (miRNA) have been highlighted as potential circulating biomarkers and as therapeutic targets for breast cancer. Recent evidence suggests that miRNAs are transported in protective microvesicles called exosomes, ...
Optimising the maturation rate of arteriovenous fistula (AVF) in patients with end stage renal disease (ESRD)
(2016-01-25)
A well-functioning Arteriovenous Fistula (AVF) has been shown to be the best modality for access in patients with end-stage kidney disease going for dialysis. Maturation of AVF is complex and depends on various biomechanical ...
Exosome-encapsulated microRNAs as circulating biomarkers for breast cancer
(2016-06-15)
Breast cancer is a heterogeneous group of diseases survival from which depends on stage at diagnosis. The development of blood-based biomarkers which may facilitate earlier detection and possibly subtype delineation remains ...
MicroRNAs as biomarkers and therapeutics in breast cancer
(2017-05-25)
Micro(mi)RNAs have potential as both therapeutics and circulating biomarkers of disease. This study investigates potential breast cancer biomarkers miR-138, miR-504 and miR-379. Furthermore, it investigates the impact that ...
Molecular mechanisms and tumour heterogeneity in breast cancer
(2014-05-07)
MicroRNAs play a critical role in regulation of gene expression and are known to be dysregulated in breast cancer. The aim of this study was investigate four microRNAs miR-875-5p, miR-339-5p, miR-10a and miR-379 which were ...