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Understanding the multifunctional domains of controller protein Centrin2
(NUI Galway, 2018-12-21)
Centrin2 is a centrosomal calcium-binding protein that plays a critical role in centriole dynamics and ciliogenesis. Structurally, it has four calcium-binding EF- hand motifs. Most of the cellular centrin2 is not associated ...
Conservation biology of the European eel (Anguilla anguilla) on a hydropower-regulated Irish river
(2012-07-31)
The European eel (Anguilla anguilla) has a complex lifecycle, involving catadromous migration between marine spawning grounds and continental growth habitat. European eel stocks have undergone a serious population collapse, ...
The natural adhesive of the goose barnacle Lepas anatifera: The functional morphology and chemistry of the adhesive gland and an investigation of the adhesive proteins
(2013-12-25)
The adhesive and adhesive glands of the stalked barnacle Lepas anatifera were investigated using a wide range of techniques to characterise them and compare them to distantly related acorn barnacles, as well as other ...
A functional approach to characterising the microbial communities underpinning low temperature anaerobic digestion
(2013-03-06)
Low-temperature anaerobic digestion (LTAD) presents a sustainable, cost-efficient technology for the treatment of a vast array of wastewater streams. However, this microbially-mediated process requires further understanding ...
Molecular investigation into the roles of Sigma B and the Stressosome in the response of Listeria monocytogenes to environmental stress
(NUI Galway, 2019-07-15)
The alternative sigma factor, SigB, has been studied extensively in Listeria monocytogenes, Bacillus subtilis and Staphylococcus aureus, and is known to regulate the general stress response in these bacteria. The activation ...
Identification of decisive molecular interactions regulating resistance to apoptosis in tumour cells
(14-07-04)
TRAIL is a member of the TNF family of cytokines which can selectively induce apoptosis in cancerous cells. For this reason recombinant TRAIL is being considered for the treatment of cancer. During their development cancer ...
Predation, competition and conservation: An investigation of the behavioural ecology of the internationally-protected Geomalacus maculosus
(NUI Galway, 2019-02-14)
The Kerry spotted slug Geomalacus maculosus is protected internationally on the basis of its limited global distribution in that it occurs only in the west of Ireland and north-western Iberia. Spanish populations are listed ...
Reverse Genetic Analysis of Pericentrin Functions
(2012-06-11)
The centrosome is a subcellular organelle that organises the mitotic spindle microtubules to ensure accurate segregation of chromosomes during cell division. Most animal centrosomes comprise a pair of centrioles which are ...
The role of the pine marten in Irish squirrel population dynamics
(2013-09-19)
There are two squirrel species found in Ireland. The native red squirrel, Sciurus vulgaris, and the invasive North American grey squirrel, Sciurus carolinensis. In Ireland, the UK and Italy the grey squirrel threatens ...
Regulators of TRAIL resistance in normal and transformed cells
(2015-05-26)
TRAIL is a member of the Tumor Necrosis Factor superfamily which was shown to be able to induce apoptotic cell death in a wide variety of transformed cells, leaving normal, healthy cells unharmed. However, approximately ...