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The glycosylation signature of human urinary extracellular vesicles
(2015-12-22)
Cells of virtually all organs and tissues are known to release large numbers of subcellular particles called extracellular vesicles (EVs) into bodily fluids such as blood and urine. There has been a growing interest in ...
microRNA-mediated intercellular communication in the primary breast tumour microenvironment
(2014-08-30)
microRNAs (miRNA) have been highlighted as potential circulating biomarkers and as therapeutic targets for breast cancer. Recent evidence suggests that miRNAs are transported in protective microvesicles called exosomes, ...
Chronic nitric oxide exposure induces prostate cell carcinogenesis, involving genetic instability and a pro-tumorigenic secretory phenotype
(2015-11-05)
Prostate cancer is the second most commonly diagnosed cancer, and ranked third in the causes of death from cancer in Irish men. Inflammation has been implicated in prostate carcinogenesis, with the overexpression of NOS2 ...
Methamphetamine exposure during pregnancy: Neurodevelopmental consequences for the offspring
(2016-04-05)
Methamphetamine (MA) abuse during pregnancy is a significant concern worldwide. Improving our understanding of the consequences of such exposure on the child is paramount and animal models provide an alternative method of ...
Maintenance of the spindle assembly checkpoint by PLK1 and CDC7 kinases and characterisation of cell lines carrying mutations in the genes coding for the CDC7 regulatory subunits
(2016-11-15)
The Spindle Assembly Checkpoint (SAC) ensures that accurate chromosome segregation occurs, by preventing progression into anaphase until all kinetochore-microtubule attachments are stable and bi-polar. During a mitotic ...
Allogeneic cell therapy for osteoarthritis
(2016-05-11)
Osteoarthritis is a debilitating multi-factorial joint disease which currently has no cure. Due to the significant immune cell mediated component in this disease a therapy which can modulate this inflammation and promote ...
The role of glycosylation in regulatory T-cell biology
(2016-12-14)
Regulatory T-cells (T-reg) play a pivotal role in maintaining immune homeostasis and tolerance. There has been a significant amount of research devoted to understanding their physiological mechanisms of action and the ...
Topics in cocyclic development of pairwise combinatorial designs
(2015-10-14)
This thesis is a compilation of results dealing with cocyclic development of pairwise combinatorial designs. Motivated by a classification of the indexing and extension groups of the Paley Hadamard matrices due to de ...
Phenotypic and functional heterogeneity of intermediate monocytes in healthy adults.
(2015-09-30)
Human blood monocytes are currently classified into three subsets: CD14++CD16- “Classical”, CD14++CD16+ “Intermediate” and CD14+CD16++ “Non-Classical”. Distinct functional differences between Classical and Non-Classical ...
The role of the endocannabinoid system in the affective modulation of pain
(2015-09-30)
Pain represents a major unmet clinical need and affects a large number of individuals worldwide. Numerous studies indicate a very high prevalence of chronic pain comorbid with psychiatric disorders such as anxiety and ...