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Estrogen deficiency alters the mechanobiological responses of osteoblasts and osteocytes
(NUI Galway, 2020-07-03)
Osteoporosis is most commonly manifested following menopause when estrogen
production is deficient and, as a result, bone loss and changes in bone composition
occur leading to bone fractures. Estrogen inhibits bone ...
Estrogen withdrawal in osteocytes results in altered integrin function, primary cilium elongation, and increased pro-osteoclastogenic signalling
(NUI Galway, 2020-06-28)
Osteocytes are the main mechanosensitive cells within bone. They detect changes in the mechanical environment and transduce them into biochemical responses (RANKL, OPG, and sclerostin) that regulate bone remodelling by ...
Mechanobiological changes during estrogen deficiency leading to bone loss
(NUI Galway, 2019-12-18)
Osteoporosis, which predominantly occurs in females, affects 200 million women worldwide and is characterised by bone loss and microarchitectural degradation, which leads to fractures, pain and immobility. Conventional ...