Now showing items 1-6 of 6
A role for nanor in early zebrafish development and validation of a neurotoxic zebrafish model of Parkinson’s disease
(NUI Galway, 2018-04-06)
Zebrafish are a versatile experimental model which have progressed the fields of many research areas through both genetic and pharmacological studies. In this thesis I studied a novel zygotic gene, nanor, in zebrafish and ...
Characterization of a novel zebrafish model of arrhythmogenic right ventricular cardiomyopathy
(NUI Galway, 2018-12-14)
Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) is a congenital heart disorder characterized by replacement of the ventricular myocardium with fibrofatty tissue. The majority of cases are due to mutations in genes ...
Epigenetic regulation of NOD-like receptor activity and expression.
(NUI Galway, 2018-11-19)
NOD-like receptors (NLRs) are a family of intracellular pathogen recognition receptors involved in the innate immune response. NOD1 and NOD2 are the best characterised members of this family, and so are the focus of this ...
The potential of injectable collagen hydrogels to enhance dopaminergic cell replacement therapies for Parkinson's disease
(NUI Galway, 2018-10-04)
Extensive pre-clinical and clinical assessment has shown that, when transplanted into the Parkinsonian brain, primary dopaminergic neurons can survive, integrate with the host system, produce dopamine and provide functional ...
The role of the endocannabinoid system in the emotional modulation of pain
(NUI Galway, 2018-09-06)
Fear-conditioned analgesia (FCA) is the robust suppression of pain that occurs upon reexposure to a context previously paired with an aversive stimulus. FCA is mediated by activation of the descending inhibitory pain ...
An examination of the effects of viral priming on neurotoxin induced synapse dysfunction and degeneration
(NUI Galway, 2018-10-19)
Over 200 years since its first description, Parkinson’s disease (PD) remains the second most common neurodegenerative disorder. Treatments are insufficient and there is still no cure. The continued lack of treatment ...