In recent years, there has been renewed interest in targeting the central opioid system as a novel strategy for the treatment of psychiatric disorders such as depression, due to its involvement in the regulation of mood, ...

Pain and negative affect (anxiety and depression) modulate one another reciprocally. However, the neurobiological mechanisms underlying this interaction are unclear. The endogenous opioid system plays a key role in regulating ...

Antimicrobial resistance (AMR) is one of the greatest threats to human health of the 21st Century, with certain antimicrobial resistant organisms classified as being a greater threat to public health than others. At the ...

The last decade has been characterized by a deluge of published scientific literature as well as data generation by biological experiments. The major impediment for the research community to unlock the knowledge contained ...

Parkinson’s disease is a progressive neurodegenerative disorder associated with the loss of dopaminergic neurons from the substantia nigra and striatum. Over time, the gold standard pharmacotherapy, L-dopa, loses its ...

Urothelial Carcinoma: Molecular Profiling & Potential Application in Clinical Practice Abstract Introduction: Urothelial carcinoma is characterised by a tendency to recurrence and risk of progression that necessitates ...

During this work, I examined a cohort of patients with severe and complicated obesity undergoing a milk-based intensive weight management programme, examining changes in various traits in the short and medium term. Firstly, ...

Stromal cells have long been studied for their putative role in maintaining tissue homeostasis, driving tissue remodeling processes during injury, and modulating inflammation by synergizing with immune cells. Studying ...

Osteoarthritis (OA) is the most common degenerative condition affecting whole joints and causing pain and cartilage degeneration, particularly in the elderly population. Inflammation of the synovium is now recognised as ...

Autism spectrum disorders (ASD), include a group of heterogeneous neurodevelopmental disorders (NDDs) characterized by impaired social interaction, and communication with restricted patterns of behaviour. The aetiology ...