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Treatment resistant hypertension in General Practice: prevalence, pseudo-resistance, and a feasibility study of prognosis
(NUI Galway, 2019-05-03)
Background.
Both the American Heart Association (AHA) in 2008 and the UK National Institute for Health and Care Excellence (NICE) in 2011 suggest the need for further research into the management of treatment resistant ...
Evaluation of human induced pluripotent stem cell-based cellular models for pathological investigation of genetic skeletal diseases
(NUI Galway, 2019-02-15)
The uniqueness of stem cells endows them with the capacity to be used as a valuable tool in the field of pathology, particularly the one from patients. Patient-specific cellular model can be generated by deriving donor-specific ...
Factors influencing diagnosis and outcome in HER2 receptor positive breast cancer
(NUI Galway, 2019-02-22)
Introduction
About 30% of breast cancers are HER2 receptor positive, these breast cancers traditionally had a poor prognosis but the introduction of targeted anti-HER2 therapy (Trastuzumab) has resulted in a vast improvement ...
Measuring and improving patient safety in general practice in Ireland
(NUI Galway, 2019-11-15)
Due to the large volume of primary care consultations and increasing patient complexity, there is substantial potential for unintentional patient harm. Measuring and monitoring of safety is essential to identify the ...
Implications of histone H2AX abundance in breast cancer
(NUI Galway, 2019-12-09)
Histones are responsible for the packaging of DNA into a eukaryotic cell nucleus, and the H2A variant H2AX plays an important role in the DNA damage response (DDR). The phosphorylated form of H2AX, known as γH2AX, has been ...
The Bangladesh National Blindness and Low Vision Survey - Identification of prevalence, causes and the need for eye care services
(NUI Galway, 2019-10-15)
Background:
Bangladesh is a densely populated, impoverished country in South Asia with inadequate health service provision for a variety of diseases including treatable ocular conditions. The aims of this comprehensive ...
Split luciferase reporters of apoptosome formation: a bio-tool to identify new drug-like molecules
(NUI Galway, 2019-12-03)
Formation of apoptosome, a key multiprotein complex in mitochondrial-mediated apoptosis, is an essential step during normal development and deregulation of this event is associated with pathological conditions. The apoptosome ...
Assessment of the consequences of gestational SSRI antidepressant exposure in the rat
(NUI Galway, 2019-10-08)
Although the most common psychotropic drugs prescribed in pregnancy are selective serotonin reuptake inhibitor (SSRI) antidepressants, their health impact on the resultant offspring is largely unknown due to the ethical ...
Regulation of emotion and cholinergic system connectivity in bipolar disorder
(NUI Galway, 2019-10-04)
Background: The human brain comprises distributed cortico-subcortical regions that are structurally and functionally connected into a network that is known as the human connectome. Understanding how connections between ...
Triple negative breast cancer: outcomes, subtypes and implications for treatment
(NUI Galway, 2019-11-30)
Triple negative breast cancer (TNBC) is a heterogeneous subtype representing 15-20% of all breast cancers and is associated with a poor prognosis, despite the advances made in other breast cancer subtypes. TNBC is defined ...