The DNA is continually under treat of being damaged by both endogenous and exogenous sources such as reactive oxygen species produced during normal cell metabolism or ionising radiation. It is vital for the maintenance of ...

Chronic or unresolved stress can lead to cell death, and induction of apoptosis is crucial when the cellular adaptive mechanisms are not able to resolve persistent stress. Malfunction of the apoptotic process caused by ...

Males absent on the first (MOF), also known as hMOF, MYST1, or KAT8, is a lysine acetyltransferase responsible for bulk acetylation of Histone H4 at lysine 16 (H4K16ac), though it has also been shown to acetylate several ...

The nucleolus, the largest sub-nuclear structure, forms around arrays of ribosomal RNA genes, termed nucleolar organizer regions (NORs). As the site of ribosome biogenesis, nucleolar function is intrinsically linked to ...

Polyomaviruses are non-evenloped circular DNA viruses that cause severe polyomavirus-associated diseases in immune compromised individuals. The diseases associated with these viruses have been on the rise due to myriad of ...

CTG•CAG repeat expansions are the underlying genetic cause for at least 12 inherited neurological disorders, including Huntington’s disease (HD) and myotonic dystrophy type I (DM1). Trinucleotide repeats (TNRs) are very ...

Chromatin is a dynamic complex that controls access to genetic information by undergoing structural reconfigurations. Understanding this dynamic can provide insights into the biological implications of chromatin ...

Centromeres are distinct epigenetic loci present in single copy per chromosome. Defined by the presence of the histone H3 variant CENP-A, centromeres play a vital role in chromosome segregation via the kinetochore and ...