Background. Both the American Heart Association (AHA) in 2008 and the UK National Institute for Health and Care Excellence (NICE) in 2011 suggest the need for further research into the management of treatment resistant ...

Purpose: To develop a subchondral defect in a rabbit model and assess cartilage repair using a mesenchymal stem cell-seeded scaffold. Materials and Methods: To achieve this goal, a bovine explant model and two pilot ...

Parkinson’s disease is a multifaceted neurodegenerative disorder with no curative treatment. A key aspect in the pathogenesis of Parkinson’s disease is inflammation, which is initially triggered by dying neurons and which ...

Introduction: ARDS is a syndrome of acute respiratory failure that presents with progressive arterial hypoxemia, dyspnea, and a marked increase in the work of breathing. Mechanical ventilation is necessary to support life ...

The focus of this work was to develop and validate in vitro cell culture models of neurodegenerative diseases, with a focus on Amyotrophic Lateral Sclerosis (ALS). ALS is a devastating neurodegenerative disease characterized ...

Peripheral Arterial Diseases (PAD) is a chronic and debilitating disease caused due to narrowing and hardening of arteries, that results in progressive deterioration of blood flow to the limbs. PAD commonly occurs in the ...

Interferon-α (IFN-α) is a pro-inflammatory cytokine used for the treatment of hepatitis B and C as well as various malignancies. However, therapy is often associated with neuropsychiatric side effects, including depression ...

Cells of virtually all organs and tissues are known to release large numbers of subcellular particles called extracellular vesicles (EVs) into bodily fluids such as blood and urine. There has been a growing interest in ...

Human blood monocytes, recently classified as classical (CD14++CD16-), intermediate (CD14++CD16+) and non-classical (CD14-CD16++) are reported to be dysregulated in chronic kidney disease (CKD) and may play a role in ...

Regulatory T-cells (T-reg) play a pivotal role in maintaining immune homeostasis and tolerance. There has been a significant amount of research devoted to understanding their physiological mechanisms of action and the ...