Search
Now showing items 1-10 of 85
Modelling of Inhalation Exposures to Pharmaceutical Agents
(2011-09-09)
Assessment of worker's exposure is becoming increasingly critical in the pharmaceutical industry as drugs of higher potency are being manufactured. Also the batch nature of operations often makes it difficult to obtain ...
DNA hybridisation detection on chemically modified electrodes with bioelectrocatalytic amplification of signal
(2011-12-22)
Electrochemical detection of DNA hybridization is a viable alternative to optical and radio-labelled techniques. The benefits of using biosensors based on electrochemical systems are: high sensitivity, possible development ...
The Effects of Electron-Withdrawing Ring Substituents on the Reactivity of Cyclopentadienyl Ruthenium Complexes
(2011-09-09)
This thesis describes the synthesis of ruthenium complexes which contain
cyclopentadienyl ligands with electron-withdrawing ring substituents and the effects of
these substituents on the reactivity of the metal centre. ...
Functional genomics of microrna- directed regulation of tumorigenesis in human cancer cells
(2011-09-30)
In the past few decades, microRNAs emerged as key regulators of gene expression in many fundamental biological processes such as development and differentiation as well as diseases. There are thousands of microRNAs that ...
Identification of prognostic targets in breast cancer using immunohistochemical and in situ hybridisation methodologies
(2011-12-16)
Advances in our understanding of the molecular mechanisms underlying breast cancer are leading to improvements in its management. Many of the recent gene-based signatures developed for breast cancer have highlighted the ...
Irish planters, Atlantic merchants: the development of St. Croix, Danish West Indies, 1750-1766
(2011-05)
The West Indian island of St. Croix became a colony of the Kingdom of DenmarkNorway in 1733.1 Despite this, it remained undeveloped until the late 1740s when investment in the large-scale production of sugarcane began in ...
Regulation and assembly of the associated network in human cells
(2011-10)
Centromeres are the chromosomal loci which are responsible for the equal segregation of sister chromatids to daughter cells during mitosis, by directing the assembly of kinetochores. Despite being involved in the faithful ...
Family Support as an Approach to Working with Children and Families in Ireland: An Explorative Study of Past and Present Perspectives among Pioneers and Practitioners
(2011-08-09)
In Ireland, the value and merit of Family Support as an approach to working with children is debated and contested. From a policy and practice perspective, Family Support is at times recognised and applauded as a worthwhile ...
Cell Cycle-dependence of cisplatin-and carboplatin-induced dna damage
(2011-09-30)
Platinum-based chemotherapeutic drugs such as cisplatin and carboplatin induce intra- and interstrand crosslinks, resulting in replication arrest, and cell death. Translesion synthesis by DNA polymerase eta, is one way in ...
An Infrastructure for Privacy-Enabled Sharing of Context Data
(2011-08-29)
The concept of context originated in the ubiquitous computing domain where information regarding the user's situation was gathered using sensing devices, allowing the application to automatically adapt according to the ...