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Role of Rad9 cell cycle phosphorylation in the regulation of Chk1 activation
DNA damage checkpoints are triggered in response to DNA insults. Once activated, these pathways prevent replication and segregation of the damaged DNA. In addition to cell cycle delays they regulate repair, transcription ...
Analysis of Saccharomyces cerevisiae Mec1 and Rad9 functions in the DNA Damage Response
The maintenance of genome integrity is critical for cell proliferation and survival of all organisms. Central to the DNA Damage Response are signal-transduction pathways, termed DNA damage checkpoints, conserved from ...
Analysis of the DNA damage response in model systems
The integrity of our DNA is constantly threatened by endogenous and exogenous sources of damage. In the absence of sufficient repair mechanisms, this damage can lead to mutations, potentially resulting in the development ...