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The role of the endogenous opioid system in hyperalgesia associated with negative affect
(NUI Galway, 2020-02-26)
Pain and negative affect (anxiety and depression) modulate one another reciprocally. However, the neurobiological mechanisms underlying this interaction are unclear. The endogenous opioid system plays a key role in regulating ...
Optogenetic investigations into the role of glutamatergic neurons of the anterior cingulate cortex in sensory and affective components of pain
(NUI Galway, 2019-11-15)
Pain consists of sensory-discriminative and affective-motivational components, which can share a reciprocal relationship. The anterior cingulate cortex (ACC) plays an important role in top-down control and the affective ...