Now showing items 1-1 of 1
Development of drugs targeting the human tRNA ligase RtcB in breast cancer
(NUI Galway, 2019-02-15)
The RNA ligase RtcB has been shown to regulate RNA function by direct exon ligation of spliced XBP1 messenger RNA cleaved by the endoplasmic reticulum (ER) stress sensor IRE1α. Ligation by RtcB leads to the expression of ...