Browsing University of Galway Theses by Issue Date
Now showing items 41-60 of 2273
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Clinical Applications of Molecular Profiling in Colorectal Cancer
(2011-06)Despite developments in diagnosis and treatment, 20% of colorectal cancer (CRC) patients present with metastatic disease and 30% of cases recur after curative surgery. Furthermore, the molecular factors involved in prognosis ... -
Functional dissection of the Smc5/6 complex: roles of the SUMO ligase Nse2/Mms21 in the maintenance of genome stability
(2011-06)Nse2/ Mms21 is an E3 SUMO ligase component of the Smc5/6 complex, which plays multiple roles in maintaining genome stability. To study the functions of the vertebrate Nse2 orthologue, we generated Nse2-deficient chicken ... -
Hypertextualized Virtual Environments: Dual-Mode User Interface Design
(2011-06-03)This thesis develops a novel strategy for accessing Hypertextualized Virtual Environments (HiVEs), integrated information spaces where symbolic (hypertext) and visual (3D graphics) data are simultaneously available and ... -
The Public Value of eGovernment
(2011-06-05)The ultimate question about the success of eGovernment depends on how citizens perceive its value. Although the literature highlights the primacy of the user in evaluating Information Systems (IS), little is known about ... -
Multidimensional isotropic and anisotropic investigation of the Tajo Basin subsurface - A novel anisotropic inversion approach for subsurface cases with oblique geoelectric strike directions
(2011-07-05)The Tajo Basin and Betic Cordillera are the areas investigated by the first phase of the PICASSO (Program to Investigate the Convective Alboran Sea System Overturn) project in south-central Spain. The magnetotelluric (MT) ... -
Towards a Risk Management Framework for Quality, Environmental and Health & Safety Management Systems in Regulated Environments
(2011-07-11)Whilst large-scale manufacturing in Ireland has seen a general decline in recent years, exceptions to this rule have been the medical device and pharmaceutical sectors which have seen continual growth. These sectors differ ... -
First Synthesis of an Aziridinyl Fused Pyrrolo[1,2-a]benzimidazole and Cytotoxicity Evaluation of Various Imidazobenzimidazolequinones Towards Human Normal and Cancer Cell Lines
(2011-07-13)Chapter 1 provides a review of aziridine containing anti-tumour agents and some key syntheses of the aziridinomitosene skeleton. A novel protocol for aziridine ring fusion is described leading to the preparation of the ... -
Shack-Hartmann Wavefront Sensing of Optical Vortices in a Turbulent Field
(2011-07-18)An optical vortex is a point on an optical wavefront where there is a null of intensity and the phase is undefined. When the phase is defined over the range 2 pi radians, as is commonly done, the phase surrounding the ... -
Marine Spatial Planning from an Irish perspective: Towards Best Practice in Integrated Maritime Governance
(2011-07-29)Ireland with its extensive seas, belatedly being recognised as a significant development resource. There is evidence that a diverse range of stakeholders at national and local levels in Ireland are positively disposed ... -
Computational Studies of Hypericin and Porphyrin Derivatives for Photodynamic Therapy - Spectra, Membrane Simulations, and Protein Interactions
(2011-08)Photosensitizing compounds with potential application in anticancer treatment with photodynamic therapy were investigated by means of computational methods in the studies presented in this thesis. Hypericin and brominated ... -
Removal of organic carbon, nitrogen and phosphorus from wastewater using a novel biofilm reactor
(2011-08-08)During this research study, a pumped flow biofilm reactor (PFBR) technology developed at NUI Galway for decentralised wastewater treatment was examined at laboratory scale and field scale. The PFBR technology comprised two ... -
Family Support as an Approach to Working with Children and Families in Ireland: An Explorative Study of Past and Present Perspectives among Pioneers and Practitioners
(2011-08-09)In Ireland, the value and merit of Family Support as an approach to working with children is debated and contested. From a policy and practice perspective, Family Support is at times recognised and applauded as a worthwhile ... -
Synthesis of s-glycolipids and peptidomimetics
(2011-08-19)Chapters one and two of this thesis describe the synthesis of two novel glycosphingolipid derivatives. Glycosphingolipids are amphiphilic molecules consisting of a carbohydrate head group glycosidically linked to a sphingoid ... -
Synthesis of S-glycolipids and peptidomimetics
(2011-08-19)Chapters one and two of this thesis describe the synthesis of two novel glycosphingolipid derivatives. Glycosphingolipids are amphiphilic molecules consisting of a carbohydrate head group glycosidically linked to a sphingoid ... -
Synthesis and Anti-Cancer Activity of Novel Imidazo[5,4-f]benzimidazolequinones
(2011-08-24)Chapter 1; A literature review of chemotherapeutic agents, bioreductive prodrugs and polycyclic diazoles, along with the aims and objects of the thesis is presented. Chapter 2; A review of 'oxidative' homolytic aromatic ... -
Vision Algorithms and Systems for Vehicle and Pedestrian Detection in Night Time Conditions Using Vehicle Mounted Cameras
(2011-08-24)Statistics show that a disproportionate amount of road fatalities occur at night-time despite the greatly reduced volume of traffic on roads. This thesis describes a system aimed at addressing this issue by automatically ... -
Semantic Service Oriented Architecture - Component Model, Reference Architecture and Evaluated Prototype
(2011-08-24)This dissertation presents a component model, reference architecture and peer-evaluated prototype for Semantic Service Oriented Architecture (SSOA). Semantic Web service technology, derived from the combination of the ... -
The diffusion of global human resource information technology in the subsidiaries of a US multinational corporation
(2011-08-26)The majority of multinational corporations (MNC) utilise some form of global human resource information technology (GHRIT) to collect, store and analyse employee data. The literature suggests that the use of GHRIT has the ... -
An Infrastructure for Privacy-Enabled Sharing of Context Data
(2011-08-29)The concept of context originated in the ubiquitous computing domain where information regarding the user's situation was gathered using sensing devices, allowing the application to automatically adapt according to the ... -
Online Shop Presentation Modes for Consumer Decision Making and Flow Experiences
(2011-08-29)This research investigates the influence of product record presentation modes on the process and outcomes of online shopping. Experiments investigated eight combinations of product presentation modes by partnering with an ...