dc.contributor.author | Stack, A. G. | |
dc.contributor.author | Donigiewicz, U. | |
dc.contributor.author | Abdalla, A. A. | |
dc.contributor.author | Weiland, A. | |
dc.contributor.author | Casserly, L. F. | |
dc.contributor.author | Cronin, C. J. | |
dc.contributor.author | Nguyen, H. T. | |
dc.contributor.author | Hannigan, A. | |
dc.date.accessioned | 2018-09-20T16:25:21Z | |
dc.date.available | 2018-09-20T16:25:21Z | |
dc.date.issued | 2014-03-14 | |
dc.identifier.citation | Stack, A. G. Donigiewicz, U.; Abdalla, A. A.; Weiland, A.; Casserly, L. F.; Cronin, C. J.; Nguyen, H. T.; Hannigan, A. (2014). Plasma fibrinogen associates independently with total and cardiovascular mortality among subjects with normal and reduced kidney function in the general population. QJM 107 (9), 701-713 | |
dc.identifier.issn | 1460-2725,1460-2393 | |
dc.identifier.uri | http://hdl.handle.net/10379/13993 | |
dc.description.abstract | Background: The contribution of novel risk factors to mortality in chronic kidney disease remains controversial.
Aim: To explore the association of plasma fibrinogen with mortality among individuals with normal and reduced kidney function.
Methods: We identified 9184 subjects, age 40 and over from the Third National Health and Nutrition Examination Survey (1988-94) with vital status assessed through 2006. Plasma fibrinogen was modeled as continuous variable and in quartile groups (0 to <7.7, 7.7 to <9.0, 9.0 to <10.5 and 510.5 >= mu mol/l) with total and cardiovascular mortality across categories of glomerular filtration rate (eGFR); <60, 60-90, >90 ml/min/1.73m(2) using Cox regression.
Results: In multivariate analysis, the adjusted hazard ratio (HR) per 1 mu mol/l (34 mg/dl) increase in fibrinogen was 1.07 [95% confidence interval (CI) 1.04-1.09] for total mortality and 1.06 (95% CI 1.03-1.09) for cardiovascular mortality. The adjusted HR for total mortality was 1.05 (1.01-1.09) for subjects with eGFR 60-90 ml/min/1.73m(2) and 1.06 (1.02-1.10) for subjects with eGFR <60 ml/min/1.73m(2). Subjects in the highest quartiles within each eGFR category; >90, 60-90 and <60 ml/min/1.73m(2) experienced HRs of 1.45 (95% CI 1.03-2.03), 1.35 (95% CI 1.00-1.83) and 1.72 (95% CI 1.14-2.58), respectively, compared with subjects in the lowest quartile group. The patterns were similar for cardiovascular mortality.
Conclusions: Plasma fibrinogen associates with mortality among subjects with mild to moderate kidney impairment as it does in subjects with normal kidney function and should be considered a therapeutic target for cardiovascular risk reduction. | |
dc.publisher | Oxford University Press (OUP) | |
dc.relation.ispartof | QJM | |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Ireland | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/3.0/ie/ | |
dc.subject | coronary-heart-disease | |
dc.subject | glomerular-filtration-rate | |
dc.subject | individual participant metaanalysis | |
dc.subject | nontraditional risk-factors | |
dc.subject | dialysis patients | |
dc.subject | serum creatinine | |
dc.subject | atherosclerosis | |
dc.subject | predictor | |
dc.subject | products | |
dc.subject | equation | |
dc.title | Plasma fibrinogen associates independently with total and cardiovascular mortality among subjects with normal and reduced kidney function in the general population | |
dc.type | Article | |
dc.identifier.doi | 10.1093/qjmed/hcu057 | |
dc.local.publishedsource | https://academic.oup.com/qjmed/article-pdf/107/9/701/4466371/hcu057.pdf | |
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