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Now showing items 101-110 of 121
Inhibition of human BK polyomavirus replication by small noncoding RNAs
(American Society for Microbiology Journals, 2011)
Small noncoding RNAs regulate a variety of cellular processes, including genomic imprinting, chromatin remodeling, replication, transcription, and translation. Here, we report small replication-regulating RNAs (srRNAs) ...
Kinetics in signal transduction pathways involving promiscuous oligomerizing receptors can be determined by receptor specificity: Apoptosis induction by TRAIL
(American Society for Biochemistry and Molecular Biology, 2012)
Here we show by computer modeling that kinetics and outcome of signal transduction in case of hetero-oligomerizing receptors of a promiscuous ligand largely depend on the relative amounts of its receptors. Promiscuous ...
Cell cycle-dependent mobility of Cdc45 determined in vivo by fluorescence correlation spectroscopy
(Public Library of Science, 2012-04-19)
Eukaryotic DNA replication is a dynamic process requiring the co-operation of specific replication proteins. We measured the mobility of eGFP-Cdc45 by Fluorescence Correlation Spectroscopy (FCS) in vivo in asynchronous ...
Cell cycle-dependent formation of Cdc45-Claspin complexes in human cells is compromized by UV-mediated DNA damage
(Wiley, 2013-08-02)
The replication factor Cdc45 has essential functions in the initiation and elongation steps of eukaryotic DNA replication and plays an important role in the intra-S-phase checkpoint. Its interactions with other replication ...
The performance of antimicrobial susceptibility testing programmes relevant to aquaculture and aquaculture products
(Food and Agriculture Organization of the United Nations (FAO), 2019)
Antimicrobial susceptibility testing of bacteria isolated from aquatic animals and their
environments may be performed either as part of a monitoring or surveillance programme or
to provide guidance for clinical treatments ...
Altered gene regulation as a candidate mechanism by which ciliopathy gene SDCCAG8 contributes to schizophrenia and cognitive function
(Oxford University Press (OUP), 2019-12-23)
Mutations in genes that encode centrosomal/ciliary proteins cause severe cognitive deficits, while common single-nucleotide polymorphisms in these genes are associated with schizophrenia (SZ) and cognition in genome-wide ...
Nerve Growth Factor in Cancer Cell Death and Survival
(MDPI, 2011-02)
One of the major challenges for cancer therapeutics is the resistance of many tumor cells to induction of cell death due to pro-survival signaling in the cancer cells. Here we review the growing literature which shows that ...
Pectin metabolism and assembly in the cell wall of the charophyte green alga penium margaritaceum
(American Society of Plant Biologists, 2014-03-20)
The pectin polymer homogalacturonan (HG) is a major component of land plant cell walls and is especially abundant in the middle lamella. Current models suggest that HG is deposited into the wall as a highly methylesterified ...
HSP72 Protects Cells from ER Stress-induced Apoptosis via Enhancement of IRE1¿-XBP1 Signaling through a Physical Interaction
(2010)
Endoplasmic reticulum (ER) stress is a feature of secretory cells and of many diseases including cancer, neurodegeneration, and diabetes. Adaptation to ER stress depends on the activation of a signal transduction pathway ...
Mechanisms of ER Stress-Mediated Mitochondrial Membrane Permeabilization
(2010)
During apoptosis, the process of mitochondrial outer membrane permeabilization (MOMP) represents a point-of-no-return as it commits the cell to death. Here we have assessed the role of caspases, Bcl-2 family members and ...