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Role of mitochondria in neuronal apoptosis
(Karger Publishers, 2000-12)
Apoptosis is a controlled form of cell death that participates in the demise of neuronal cells during development, neurodegenerative disorders and exposure to neurotoxic agents. In recent years, the mitochondria have emerged ...
Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling
(Wiley, 2008-06-27)
Neuronal cell death plays a role in many chronic neurodegenerative diseases with the loss of particular subsets of neurons. The loss of the neurons occurs during a period of many years, which can make the mode(s) of cell ...
Restriction of human polyomavirus BK virus DNA replication in murine cells and extracts
(2009)
BK virus (BKV) causes persistent and asymptomatic infections in most humans and is the etiologic agent of polyomavirus-associated nephropathy (PVAN) and other pathologies. Unfortunately, there are no animal models with ...
Specificity and sensitivity evaluation of novel and existing Bacteroidales and Bifidobacteria-specific PCR assays on feces and sewage samples and their application for microbial source tracking in Ireland
(Elsevier, 2009)
Three novel ruminant-specific PCR assays, an existing ruminant-specific PCR assay and five existing human-specific PCR assays, which target 16S rDNA from Bacteroidales or Bifidobacteria, were evaluated. The assays were ...
Bordetella pertussis expresses a functional type III secretion system that subverts protective innate and adaptive immune responses
(American Society for Microbiology, 2008-01)
Certain bacteria use a type III secretion system (TTSS) to deliver effector proteins that interfere with cell function into host cells. While transcription of genes encoding TTSS components has been demonstrated, studies ...
Adenylate Cyclase Toxin from Bordetella pertussis Synergizes with Lipopolysaccharide To Promote Innate Interleukin-10 Production and Enhances the Induction of Th2 and Regulatory T Cells
(American Society for Microbiology, 2004-03)
Adenylate cyclase toxin (CyaA) from Bordetella pertussis can subvert host immune responses allowing
bacterial colonization. Here we have examined its adjuvant and immunomodulatory properties and the
possible contribution ...
Identification of Components of the Sigma B Regulon in Listeria monocytogenes That Contribute to Acid and Salt Tolerance
(American Society for Microbiology, 2008-09)
Sigma B is an alternative sigma factor that controls the transcriptional response to stress in Listeria monocytogenes and is also known to play a role in the virulence of this human pathogen. In the present study we ...
Competition between the Yops of Yersinia enterocolitica for delivery into eukaryotic cells: Role of the SycE chaperone binding domain of YopE
(American Society for Microbiology, 2000-09)
A type III secretion-translocation system allows Yersinia adhering at the surface of animal cells to deliver a cocktail of effector Yops (YopH, -O, -P, -E, -M, and -T) into the cytosol of these cells. Residues or codons 1 ...
Partial reconstitution of DNA large loop repair with purified proteins from Saccharomyces cerevisiae
(OUP, 2008)
Small looped mispairs are corrected by DNA mismatch repair. In addition, a distinct process called large loop repair (LLR) corrects heteroduplexes up to several hundred nucleotides in bacteria, yeast and human cells, and ...
Mrc1, Tof1 and Csm3 inhibit CAG·CTG repeat instability by at least two mechanisms
(Springer, 2008)
Trinucleotide repeats frequently expand and contract in humans and model organisms. Protein factors that modulate this process have been found by candidate gene approaches or mutant screens for increased expansion ...