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Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling
(Wiley, 2008-06-27)
Neuronal cell death plays a role in many chronic neurodegenerative diseases with the loss of particular subsets of neurons. The loss of the neurons occurs during a period of many years, which can make the mode(s) of cell ...
Electron backscatter diffraction (EBSD) in the SEM: applications to microstructures in minerals and rocks and recent technological advancements
(Sociedad Española de la Mineralogía, 2008-09-16)
Electron backscatter diffraction (EBSD) is based on the principle that a beam of electrons generated in the scanning electron microscope (SEM) is the source of randomly scattered electrons in a specimen. The backscattered ...
Bordetella pertussis expresses a functional type III secretion system that subverts protective innate and adaptive immune responses
(American Society for Microbiology, 2008-01)
Certain bacteria use a type III secretion system (TTSS) to deliver effector proteins that interfere with cell function into host cells. While transcription of genes encoding TTSS components has been demonstrated, studies ...
Identification of Components of the Sigma B Regulon in Listeria monocytogenes That Contribute to Acid and Salt Tolerance
(American Society for Microbiology, 2008-09)
Sigma B is an alternative sigma factor that controls the transcriptional response to stress in Listeria monocytogenes and is also known to play a role in the virulence of this human pathogen. In the present study we ...
Partial reconstitution of DNA large loop repair with purified proteins from Saccharomyces cerevisiae
(OUP, 2008)
Small looped mispairs are corrected by DNA mismatch repair. In addition, a distinct process called large loop repair (LLR) corrects heteroduplexes up to several hundred nucleotides in bacteria, yeast and human cells, and ...
Mrc1, Tof1 and Csm3 inhibit CAG·CTG repeat instability by at least two mechanisms
(Springer, 2008)
Trinucleotide repeats frequently expand and contract in humans and model organisms. Protein factors that modulate this process have been found by candidate gene approaches or mutant screens for increased expansion ...
Rapid unwinding of triplet repeat hairpins by Srs2 helicase of Saccharomyces cerevisiae
(2008)
Expansions of trinucleotide repeats cause at least 15 heritable human diseases. Single-stranded triplet repeat DNA in vitro forms stable hairpins in a sequence-dependent manner that correlates with expansion risk in vivo. ...