Browsing School of Natural Sciences by Issue Date
Now showing items 21-40 of 166
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Rapid and efficient cancer cell killing mediated by high-affinity death receptor homotrimerizing TRAIL variants
(Macmillan Publishers Limited, 2010)The tumour necrosis factor family member TNF-related apoptosis-inducing ligand (TRAIL) selectively induces apoptosis in a variety of cancer cells through the activation of death receptors 4 (DR4) and 5 (DR5) and is considered ... -
Control of transfer and weak closure in fusion systems
(2010)We show that K¿ and K¿ control transfer in every fusion system on a finite p-group when p ¿ 5, and that they control weak closure of elements in every fusion system on a finite p-group when p ¿ 3. This generalizes resultsof ... -
HSP72 Protects Cells from ER Stress-induced Apoptosis via Enhancement of IRE1¿-XBP1 Signaling through a Physical Interaction
(2010)Endoplasmic reticulum (ER) stress is a feature of secretory cells and of many diseases including cancer, neurodegeneration, and diabetes. Adaptation to ER stress depends on the activation of a signal transduction pathway ... -
Mechanisms of ER Stress-Mediated Mitochondrial Membrane Permeabilization
(2010)During apoptosis, the process of mitochondrial outer membrane permeabilization (MOMP) represents a point-of-no-return as it commits the cell to death. Here we have assessed the role of caspases, Bcl-2 family members and ... -
Beyond the green: understanding the evolutionary puzzle of plant and algal cell walls
(American Society of Plant Biologists, 2010-04-26)Niklas (2000) defined plants as “photosynthetic eukaryotes,” thereby including brown, red, and green macroalgae and microalgae. These groups share several features, including the presence of a complex, dynamic, and ... -
Intracellular accumulation of high levels of gamma-aminobutyrate by Listeria monocytogenes 10403S in response to low pH: uncoupling of gamma-aminobutyrate synthesis from efflux in a chemically defined medium
(American Society for Microbiology, 2010-06)It is well established that the glutamate decarboxylase (GAD) system is central to the survival of Listeria monocytogenes at low pH, both in acidic foods and within the mammalian stomach. The accepted model proposes that ... -
Temperature-dependent phenotypic variation of Campylobacter jejuni lipooligosaccharides
(2010-11)Background:Campylobacter jejuni is a major bacterial cause of food-borne enteritis, and its lipooligosaccharide (LOS) plays an initiating role in the development of the autoimmune neuropathy, Guillain-Barré syndrome, by ... -
The Vibrio parahaemolyticus Type III Secretion Systems manipulate host cell MAPK for critical steps in pathogenesis
(BioMed Central, 2011)Background:Vibrio parahaemolyticus is a food-borne pathogen causing inflammation of the gastrointestinal epithelium. Pathogenic strains of this bacterium possess two Type III Secretion Systems (TTSS) that deliver effector ... -
The Proteasome Inhibitor Bortezomib Sensitizes AML with Myelomonocytic Differentiation to TRAIL Mediated Apoptosis
(2011)Acute myeloid leukemia (AML) is an aggressive stem cell malignancy that is difficult to treat. There are limitations to the current treatment regimes especially after disease relapse, and therefore new therapeutic agents ... -
Identification of imprinted genes subject to parent-of-origin specific expression in Arabidopsis thaliana seeds
(2011)Background: Epigenetic regulation of gene dosage by genomic imprinting of some autosomal genes facilitates normal reproductive development in both mammals and flowering plants. While many imprinted genes have been identified ... -
High-resolution analysis of parent-of-origin allelic expression in the Arabidopsis endosperm.
(2011)Genomic imprinting is an epigenetic phenomenon leading to parent-of-origin specific differential expression of maternally and paternally inherited alleles. In plants, genomic imprinting has mainly been observed in the ... -
Premitotic Assembly of Human CENPs -T and -W Switches Centromeric Chromatin to a Mitotic State.
(2011)Centromeres are differentiated chromatin domains, present once per chromosome, that direct segregation of the genome in mitosis and meiosis by specifying assembly of the kinetochore. They are distinct genetic loci in that ... -
Inhibition of human BK polyomavirus replication by small noncoding RNAs
(American Society for Microbiology Journals, 2011)Small noncoding RNAs regulate a variety of cellular processes, including genomic imprinting, chromatin remodeling, replication, transcription, and translation. Here, we report small replication-regulating RNAs (srRNAs) ... -
Fractures interpreted from acoustic formation imaging technology: Correlation to permeability
(Stanford University, 2011-01-31)Permeable feed zones in geothermal wells are commonly identified using well profiles of temperature, pressure and fluid velocity measured at different injection rates during well completion testing and heat-up. While this ... -
Novel Multiplex Real-Time PCR Diagnostic Assay for Identification and Differentiation of Mycobacterium tuberculosis, Mycobacterium canettii, and Mycobacterium tuberculosis Complex Strains
(Journal of Clinical Microbiology, 2011-02)Tuberculosis (TB) in humans is caused by members of the Mycobacterium tuberculosis complex (MTC). Rapid detection of the MTC is necessary for the timely initiation of antibiotic treatment, while differentiation between ... -
Nerve Growth Factor in Cancer Cell Death and Survival
(MDPI, 2011-02)One of the major challenges for cancer therapeutics is the resistance of many tumor cells to induction of cell death due to pro-survival signaling in the cancer cells. Here we review the growing literature which shows that ... -
Evolution and diversity of plant cell walls: from algae to flowering plants
(Annual Reviews, 2011-02-22)All photosynthetic multicellular Eukaryotes, including land plants and algae, have cells that are surrounded by a dynamic, complex, carbohydrate-rich cell wall. The cell wall exerts considerable biological and biomechanical ... -
A Novel Multiplex Real-Time PCR for the Identification of Mycobacteria Associated with Zoonotic Tuberculosis
(PLoS ONE, 2011-08-09)Background: Tuberculosis (TB) is the leading cause of death worldwide from a single infectious agent. An ability to detect the Mycobacterium tuberculosis complex (MTC) in clinical material while simultaneously differentiating ... -
Statistical corrections of fracture sampling bias in boreholes from acoustic televiewer logs
(New Zealand Geothermal Workshop, 2012)Targeting structurally controlled permeability remains a challenge in high temperature geothermal fields, because of the difficulties in characterising faults and fractures and their behaviour within the reservoir. The ... -
Quantifying the stress distribution at the Rotokawa Geothermal Field, New Zealand
(New Zealand Geothermal Workshop, 2012)Knowledge of the orientation and magnitude of the principal stresses can be used to model the behavior of faults and fractures, and determine how they may influence fracture hosted permeability in geothermal reservoirs. ...