Browsing School of Natural Sciences by Title
Now showing items 66-85 of 166
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A gene regulatory network underlying the formation of pre-placodal ectoderm in Xenopus laevis
(BioMed Central, 2018-06-16)Background: The neural plate border ectoderm gives rise to key developmental structures during embryogenesis, including the neural crest and the preplacodal ectoderm. Many sensory organs and ganglia of vertebrates develop ... -
Generation of a panel of high affinity antibodies and development of a biosensor-based immunoassay for the detection of okadaic acid in shellfish
(Elsevier, 2015-07-10)Okadaic acid (OA) and its derivatives, DTX-1 and DTX-2, are marine biotoxins associated with diarrhetic shellfish poisoning. Routine monitoring of these toxins relies on the mouse bioassay. However, due to the technical ... -
Generation of rationally-designed nerve growth factor (NGF) variants with receptor specificity
(Elsevier, 2017-11-03)Nerve growth factor (NGF) is the prototypic member of the neurotrophin family and binds two receptors, TrkA and the 75 kDa neurotrophin receptor (p75NTR), through which diverse and sometimes opposing effects are mediated. ... -
Genes influenced by MEF2C contribute to neurodevelopmental disease via gene expression changes that affect multiple types of cortical excitatory neurons
(Oxford University Press (OUP), 2020-09-25)Myocyte enhancer factor 2 C (MEF2C) is an important transcription factor during neurodevelopment. Mutation or deletion of MEF2C causes intellectual disability (ID) and common variants within MEF2C are associated with ... -
Genes regulated by BCL11B during T‐cell development are enriched for de novo mutations found in schizophrenia patients
(Wiley, 2020-07-29)While abnormal neurodevelopment contributes to schizophrenia (SCZ) risk, there is also evidence to support a role for immune dysfunction in SCZ.BCL11B, associated with SCZ in genome-wide association study (GWAS), is a ... -
Geographical location influences the composition of the gut microbiota in wild house mice (Mus musculus domesticus) at a fine spatial scale
(Public Library of Science, 2019-09-26)The composition of the mammalian gut microbiota can be influenced by a multitude of environmental variables such as diet and infections. Studies investigating the effect of these variables on gut microbiota composition ... -
Geothermal structural geology in New Zealand: Innovative characterisation and micro-analytical techniques
(International Geothermal Association, 2016-11-23)Many of New Zealand's geothermal reservoirs are hosted in rocks with low intrinsic permeability. As such, successful development of these resources relies on understanding the role subsurface structures, such as fractures ... -
Glycomics microarrays reveal differential in situ presentation of the biofilm polysaccharide Poly-N-acetylglucosamine on Acinetobacter baumannii and Staphylococcus aureus cell surfaces
(MDPI, 2020-04-02)The biofilm component poly-N-acetylglucosamine (PNAG) is an important virulence determinant in medical-device-related infections caused by ESKAPE group pathogens including Gram-positive Staphylococcus aureus and Gram-negative ... -
Heterogeneity of structure and stress in the Rotokawa Geothermal Field, New Zealand
(American Geophysical Union (AGU), 2015-02-12)Geometric characterization of a geothermal reservoir's structures, and their relation to stress field orientation, is vital for resource development. Subsurface structure and stress field orientations of the Rotokawa ... -
High-resolution analysis of parent-of-origin allelic expression in the Arabidopsis endosperm.
(2011)Genomic imprinting is an epigenetic phenomenon leading to parent-of-origin specific differential expression of maternally and paternally inherited alleles. In plants, genomic imprinting has mainly been observed in the ... -
HSP72 Protects Cells from ER Stress-induced Apoptosis via Enhancement of IRE1¿-XBP1 Signaling through a Physical Interaction
(2010)Endoplasmic reticulum (ER) stress is a feature of secretory cells and of many diseases including cancer, neurodegeneration, and diabetes. Adaptation to ER stress depends on the activation of a signal transduction pathway ... -
Identification of Components of the Sigma B Regulon in Listeria monocytogenes That Contribute to Acid and Salt Tolerance
(American Society for Microbiology, 2008-09)Sigma B is an alternative sigma factor that controls the transcriptional response to stress in Listeria monocytogenes and is also known to play a role in the virulence of this human pathogen. In the present study we ... -
Identification of imprinted genes subject to parent-of-origin specific expression in Arabidopsis thaliana seeds
(2011)Background: Epigenetic regulation of gene dosage by genomic imprinting of some autosomal genes facilitates normal reproductive development in both mammals and flowering plants. While many imprinted genes have been identified ... -
Identification of novel cis-regulatory elements of Eya1 in Xenopus laevis using BAC recombineering
(Nature Publishing Group, 2017-11-03)The multifunctional Eya1 protein plays important roles during the development of cranial sensory organs and ganglia, kidneys, hypaxial muscles and several other organs in vertebrates. Eya1 is encoded by a complex locus ... -
Identification of putative adhesins and carbohydrate ligands of Lactobacillus paracasei using a combinatorial in silico and glycomics microarray profiling approach
(Oxford University Press (OUP), 2019-11-11)Commensal bacteria must colonize host mucosal surfaces to exert health-promoting properties, and bind to gastrointestinal tract (GIT) mucins via their cell surface adhesins. Considerable effort has been directed towards ... -
Identifying the sources and sinks of CDOM/FDOM across the Mauritanian Shelf and their potential role in the decomposition of superoxide (O2- )
(Frontiers Media, 2016-08-03)Superoxide (O−2O2-) is a short lived reactive oxygen species (ROS) formed in seawater by photochemical or biological sources, it is important in the redox cycling of trace elements and organic matter in the ocean. The ... -
Impact of trichloroethylene exposure on the microbial diversity and protein expression in anaerobic granular biomass at 37°C and 15°C
(Hindawi Publishing Corporation, 2012-09-14)Granular biomass from a laboratory-scale anaerobic bioreactor trial was analysed to identify changes in microbial community structure and function in response to temperature and trichloroethylene (TCE). Two bioreactors ... -
In vitro comparative cytotoxicity study of a novel biocidal iodo-thiocyanate complex
(Elsevier, 2018-04-03)Novel biocides, which avoid the induction of cross-resistance to antibiotics, are an urgent societal requirement. Here, we compared the cytotoxic and bactericidal effects of a new antimicrobial agent, the iodo-thiocyanate ... -
Influence of incubation time on antimicrobial susceptibility testing of pathogenic Vibrio anguillarum and Vibrio vulnificus isolated from fish
(Elsevier, 2020-07-15)A multi-laboratory study was performed to investigate the most suitable incubation time for susceptibility tests of fish pathogens Vibrio anguillarum and Vibrio vulnificus performed at 28 degrees C. An isolate set consisting ... -
Influence of stormflow and baseflow phosphorus pressures on stream ecology in agricultural catchments
(Elsevier, 2017-03-09)Stormflow and baseflow phosphorus (P) concentrations and loads in rivers may exert different ecological pressures during different seasons. These pressures and subsequent impacts are important to disentangle in order to ...