Browsing School of Natural Sciences by Title
Now showing items 134-153 of 166
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The Proteasome Inhibitor Bortezomib Sensitizes AML with Myelomonocytic Differentiation to TRAIL Mediated Apoptosis
(2011)Acute myeloid leukemia (AML) is an aggressive stem cell malignancy that is difficult to treat. There are limitations to the current treatment regimes especially after disease relapse, and therefore new therapeutic agents ... -
Quantifying the stress distribution at the Rotokawa Geothermal Field, New Zealand
(New Zealand Geothermal Workshop, 2012)Knowledge of the orientation and magnitude of the principal stresses can be used to model the behavior of faults and fractures, and determine how they may influence fracture hosted permeability in geothermal reservoirs. ... -
Quantitative geometric description of fracture systems in an andesite lava flow using terrestrial laser scanner data
(Elsevier, 2017-06-03)Permeability hosted in andesitic lava flows is dominantly controlled by fracture systems, with geometries that are often poorly constrained. This paper explores the fracture system geometry of an andesitic lava flow formed ... -
Rapid and efficient cancer cell killing mediated by high-affinity death receptor homotrimerizing TRAIL variants
(Macmillan Publishers Limited, 2010)The tumour necrosis factor family member TNF-related apoptosis-inducing ligand (TRAIL) selectively induces apoptosis in a variety of cancer cells through the activation of death receptors 4 (DR4) and 5 (DR5) and is considered ... -
A rapid culture independent methodology to quantitatively detect and identify common human bacterial pathogens associated with contaminated high purity water
(BioMed Central, 2015-02-18)Water and High Purity Water (HPW) distribution systems can be contaminated with human pathogenic microorganisms. This biocontamination may pose a risk to human health as HPW is commonly used in the industrial, pharmaceutical ... -
Rapid screening for specific glycosylation and pathogen interactions on a 78 species avian egg white glycoprotein microarray
(Nature Research, 2017-07-25)There is an urgent need for discovery of novel antimicrobials and carbohydrate-based anti-adhesive strategies are desirable as they may not promote resistance. Discovery of novel anti-adhesive molecules from natural product ... -
Rapid unwinding of triplet repeat hairpins by Srs2 helicase of Saccharomyces cerevisiae
(2008)Expansions of trinucleotide repeats cause at least 15 heritable human diseases. Single-stranded triplet repeat DNA in vitro forms stable hairpins in a sequence-dependent manner that correlates with expansion risk in vivo. ... -
Reproducible, high-yielding, biological caproate production from food waste using a single-phase anaerobic reactor system
(BMC (part of Springer Nature), 2018-03-11)Background: Nowadays, the vast majority of chemicals are either synthesised from fossil fuels or are extracted from agricultural commodities. However, these production approaches are not environmentally and economically ... -
Response of farmland biodiversity to the introduction of bioenergy crops: effects of local factors and surrounding landscape context
(Wiley Open Access, 2013-07-19)The recent growth in bioenergy crop cultivation, stimulated by the need to implement measures to reduce net CO2 emissions, is driving major land-use changes with consequences for biodiversity and ecosystem service provision. ... -
Restriction of human polyomavirus BK virus DNA replication in murine cells and extracts
(2009)BK virus (BKV) causes persistent and asymptomatic infections in most humans and is the etiologic agent of polyomavirus-associated nephropathy (PVAN) and other pathologies. Unfortunately, there are no animal models with ... -
A review of the Rotokawa Geothermal Field, New Zealand
(Elsevier, 2015-07-29)The Rotokawa Geothermal Field of New Zealand has seen significant development over the last 20 years and has been the study site for new and innovative geological and geothermal research. This includes the one of the first ... -
A review of the shortcomings in the testing methods used and reporting of data in the literature on antimicrobial susceptibility
(European Association of Fish Pathologists, 2020-06-02)The susceptibility test protocols used in 186 published papers that reported 203 studies of the antimicrobial susceptibility of non-cholera Vibrio spp were examined. Only a very small percentage of the studies provided ... -
RIP2 enhances cell survival by activation of NF-ĸB in triple negative breast cancer cells
(Elsevier, 2018-02-06)Receptor-interacting protein 2 (RIP2) is an essential mediator of inflammation and innate immunity, but little is known about its role outside the immune system. Recently, RIP2 has been linked to chemoresistance of triple ... -
RNA from a simple-tandem repeat is required for sperm maturation and male fertility in Drosophila melanogaster
(eLife Sciences Publications, 2019-11-05)Tandemly-repeated DNAs, or satellites, are enriched in heterochromatic regions of eukaryotic genomes and contribute to nuclear structure and function. Some satellites are transcribed, but we lack direct evidence that ... -
Rock properties of Greywacke Basement hosting geothermal reservoirs, New Zealand: preliminary results
(Stanford University, 2014-02-24)Geothermal resources in New Zealand are known to be hosted in greywacke basement rocks. Fluid flow in these reservoirs and the wells that access them is controlled by fracture networks. As such it is of vital importance ... -
Role of alginate lyase in cell detachment of Pseudomonas aeruginosa
(American Society for Microbiology, 1994-07)The exopolysaccharide alginate of Pseudomonas aeruginosa was shown to be important in determining the degree of cell detachment from an agar surface. Nonmucoid strain 8822 gave rise to 50-fold more sloughed cells than ... -
Role of mitochondria in neuronal apoptosis
(Karger Publishers, 2000-12)Apoptosis is a controlled form of cell death that participates in the demise of neuronal cells during development, neurodegenerative disorders and exposure to neurotoxic agents. In recent years, the mitochondria have emerged ... -
Setting epidemiological cut-off values for bacteria isolated from aquatic animals: a toolbox for designing a 96-well plate for microdilution MIC assays
(European Association of Fish Pathologists, 2020-06-02)A workshop was held at the EAFP meeting in Porto to initiate discussion on the design of studies that could generate the data needed to set epidemiological cut-off values appropriate for application to antimicrobial ... -
Snake venom potency and yield are associated with prey‐evolution, predator metabolism and habitat structure
(Wiley, 2019-01-07)Snake venom is well known for its ability to incapacitate and kill prey. Yet, potency and the amount of venom available varies greatly across species, ranging from the seemingly harmless to those capable of killing vast ... -
Specificity and sensitivity evaluation of novel and existing Bacteroidales and Bifidobacteria-specific PCR assays on feces and sewage samples and their application for microbial source tracking in Ireland
(Elsevier, 2009)Three novel ruminant-specific PCR assays, an existing ruminant-specific PCR assay and five existing human-specific PCR assays, which target 16S rDNA from Bacteroidales or Bifidobacteria, were evaluated. The assays were ...