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dc.contributor.authorSeager, Ishla
dc.contributor.authorTravers, Simon A.
dc.contributor.authorLeeson, Michael D.
dc.contributor.authorCrampin, Amelia C.
dc.contributor.authorFrench, Neil
dc.contributor.authorGlynn, Judith R.
dc.contributor.authorMcCormack, Grace P.
dc.date.accessioned2018-09-20T16:24:14Z
dc.date.available2018-09-20T16:24:14Z
dc.date.issued2014-10-01
dc.identifier.citationSeager, Ishla; Travers, Simon A. Leeson, Michael D.; Crampin, Amelia C.; French, Neil; Glynn, Judith R.; McCormack, Grace P. (2014). Coreceptor usage, diversity, and divergence in drug-naive and drug-exposed individuals from malawi, infected with hiv-1 subtype c for more than 20 years. AIDS Research and Human Retroviruses 30 (10), 975-983
dc.identifier.issn0889-2229,1931-8405
dc.identifier.urihttp://hdl.handle.net/10379/13844
dc.description.abstractThere are few cohorts of individuals who have survived infection with HIV-1 for more than 20 years, reported and followed in the literature, and even fewer from Africa. Here we present data on a cohort of subtype C-infected individuals from rural northern Malawi. By sequencing multiple clones from long-term survivors at different time points, and using multiple genotyping approaches, we show that 5 of the 11 individuals are predicted as CXCR4 using (by >= 3/5 predictors) but only one individual is predicted as CXCR4 using by all five algorithms. Using any one genotyping approach overestimates the number of predicted CXCR4 sequences. Patterns of diversity and divergence were variable between the HIV-1 long-term survivors with some individuals showing very small amounts of variation and change, and others showing a greater amount; both patterns are consistent with what has been described in the literature.
dc.publisherMary Ann Liebert Inc
dc.relation.ispartofAIDS Research and Human Retroviruses
dc.subjecthuman-immunodeficiency-virus
dc.subjectlong-term nonprogressors
dc.subjectactive antiretroviral therapy
dc.subjectdisease progression
dc.subjecttype-1 infection
dc.subjectsouth-africa
dc.subjectneutralizing antibodies
dc.subjectelite suppressors
dc.subjectrural malawi
dc.subjectenv genes
dc.titleCoreceptor usage, diversity, and divergence in drug-naive and drug-exposed individuals from malawi, infected with hiv-1 subtype c for more than 20 years
dc.typeArticle
dc.identifier.doi10.1089/aid.2013.0240
dc.local.publishedsourcehttp://europepmc.org/articles/pmc4180525?pdf=render
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