Show simple item record

dc.contributor.authorSeager, Ishla
dc.contributor.authorLeeson, Michael D.
dc.contributor.authorCrampin, Amelia C.
dc.contributor.authorMulawa, Dominic
dc.contributor.authorFrench, Neil
dc.contributor.authorGlynn, Judith R.
dc.contributor.authorTravers, Simon A.A.
dc.contributor.authorMcCormack, Grace P.
dc.date.accessioned2018-09-20T16:24:14Z
dc.date.available2018-09-20T16:24:14Z
dc.date.issued2012-03-01
dc.identifier.citationSeager, Ishla; Leeson, Michael D. Crampin, Amelia C.; Mulawa, Dominic; French, Neil; Glynn, Judith R.; Travers, Simon A.A.; McCormack, Grace P. (2012). Hiv type 1 mutational patterns in hiv type 1 subtype c-infected long-term survivors in karonga district malawi: further analysis and correction. AIDS Research and Human Retroviruses 28 (3), 308-313
dc.identifier.issn0889-2229,1931-8405
dc.identifier.urihttp://hdl.handle.net/10379/13843
dc.description.abstractHere we present new sequence data from HIV-1 subtype C-infected long-term survivors (LTS) from Karonga District, Malawi. Gag and env sequence data were produced from nine individuals each of whom has been HIV-1 positive for more than 20 years. We show that the three amino acid deletion in gag p17 previously described from these LTS is not real and was a result of an alignment error. We find that the use of dried blood spots for DNA-based studies is limited after storage for 20 years. We also show some unlikely amino acid changes in env C2-V3 in LTS over time and different patterns of genetic divergence among LTS. Although no clear association between mutations and survival could be shown, amino acid changes that are present in more than one LTS may, in the future, be shown to be important.
dc.publisherMary Ann Liebert Inc
dc.relation.ispartofAIDS Research and Human Retroviruses
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/ie/
dc.subjectimmunodeficiency-virus type-1
dc.subjectpolymerase chain-reaction
dc.subjectblood spot specimens
dc.subjectdrug-resistance
dc.subjectrural malawi
dc.subjectDNA
dc.titleHiv type 1 mutational patterns in hiv type 1 subtype c-infected long-term survivors in karonga district malawi: further analysis and correction
dc.typeArticle
dc.identifier.doi10.1089/aid.2011.0168
dc.local.publishedsourcehttp://europepmc.org/articles/pmc3292752?pdf=render
nui.item.downloads0


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivs 3.0 Ireland
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Ireland