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dc.contributor.authorSavitz, Jonathan
dc.contributor.authorNugent, Allison C.
dc.contributor.authorCannon, Dara M.
dc.contributor.authorCarlson, Paul J.
dc.contributor.authorDavis, Rebecca
dc.contributor.authorNeumeister, Alexander
dc.contributor.authorRallis-Frutos, Denise
dc.contributor.authorFromm, Steve
dc.contributor.authorHerscovitch, Peter
dc.contributor.authorDrevets, Wayne C.
dc.date.accessioned2018-09-20T16:23:57Z
dc.date.available2018-09-20T16:23:57Z
dc.date.issued2012-03-08
dc.identifier.citationSavitz, Jonathan; Nugent, Allison C. Cannon, Dara M.; Carlson, Paul J.; Davis, Rebecca; Neumeister, Alexander; Rallis-Frutos, Denise; Fromm, Steve; Herscovitch, Peter; Drevets, Wayne C. (2012). Effects of arterial cannulation stress on regional cerebral blood flow in major depressive disorder. Scientific Reports 2 ,
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/10379/13806
dc.description.abstractIndividuals with major depressive disorder (MDD) display abnormal neurophysiological responses to psychological stress but little is known about their neurophysiological responses to physiological stressors. Using [O-15]-H2O positron emission tomography we assessed whether the regional cerebral blood flow (rCBF) response to arterial cannulation differed between patients with MDD and healthy controls (HCs). Fifty-one MDDpatients and 62 HCs were scanned following arterial cannulation and 15MDDpatients and 17 HCs were scanned without arterial cannulation. A region-of-interest analysis showed that a significantly increased rCBF of the anterior cingulate cortex and right amygdala was associated with arterial cannulation in MDD. A whole brain analysis showed increased rCBF of the right post-central gyrus, left temporopolar cortex, and right amygdala during arterial cannulation in MDD patients. The rCBF in the right amygdala was significantly correlated with depression severity. Conceivably, the limbic response to invasive physical stress is greater in MDD subjects than in HCs.
dc.publisherSpringer Nature
dc.relation.ispartofScientific Reports
dc.subjectmedial prefrontal cortex
dc.subjectpositron-emission-tomography
dc.subjectanterior cingulate cortex
dc.subjectdefault-mode network
dc.subjectpainful stimulation
dc.subjecthippocampal volume
dc.subjectglucose-metabolism
dc.subjectbipolar disorder
dc.subjectbrain activation
dc.subjectcortisol-levels
dc.titleEffects of arterial cannulation stress on regional cerebral blood flow in major depressive disorder
dc.typeArticle
dc.identifier.doi10.1038/srep00308
dc.local.publishedsourcehttp://www.nature.com/articles/srep00308.pdf
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