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A phosphate-targeted dinuclear Cu(II) complex combining major groove binding and oxidative DNA cleavage
(Oxford University Press, 2018-09-17)
Free radical generation is an inevitable consequence of aerobic existence and is implicated in a wide variety of pathological conditions including cancer, cardiovascular disease, ageing and neurodegenerative disorder. Free ...
Cocrystal forms of the BCS class IV drug sulfamethoxazole
(American Chemical Society, 2018-05-23)
Sulfamethoxazole, smz, is an antibiotic that is classified as a Biopharmaceutics Classification System (BCS) class IV, low solubility and low permeability drug. Cocrystal formation has been examined in an attempt to improve ...
Ligand design for somatostatin receptor isoforms 4 and 5
(Elsevier, 2018-11-17)
The somatostatin receptor (SSTR) isoforms, SSTR-4 and SSTR-5 are targets in numerous disorders and diseases. Although there has been some success in achieving selective isoform inhibition, structure-based drug design and ...
Application of ball milling for highly selective mechanochemical polymorph transformations
(American Chemical Society, 2018-06-07)
Milling is an important secondary processing technique in the manufacture of pharmaceuticals, primarily used as a particle size reduction process. p-Aminobenzoic acid (PABA), m-aminobenzoic acid (MABA), o-aminobenzoic acid ...
Developing detailed chemical kinetic mechanisms for fuel combustion
(Elsevier, 2018-07-01)
This paper discusses a brief history of chemical kinetic modeling, with some emphasis on the development of chemical kinetic mechanisms describing fuel oxidation. At high temperatures, the important reactions tend to be ...
A comparative study of the effect of varied reaction environments on a swirl stabilized flame geometry via optical measurements
(Elsevier, 2018-01-04)
The present work is a part of a larger experimental campaign which examines the behaviour of various fuels on a swirl stabilized flame burner configuration. Overall, detailed speciation measurements and temperature ...
In vitro comparative cytotoxicity study of a novel biocidal iodo-thiocyanate complex
(Elsevier, 2018-04-03)
Novel biocides, which avoid the induction of cross-resistance to antibiotics, are an urgent societal requirement. Here, we compared the cytotoxic and bactericidal effects of a new antimicrobial agent, the iodo-thiocyanate ...
1064 nm acoustic resolution photoacoustic microscopy
(Wiley, 2018-12-03)
Photoacoustic imaging is a noninvasive imaging technique having the advantages of high-optical contrast and good acoustic resolution at improved imaging depths. Light transport in biological tissues is mainly characterized ...
Finite bending and pattern evolution of the associated instability for a dielectric elastomer slab
(Elsevier, 2018-09-21)
We investigate the finite bending and the associated bending instability of an incompressible dielectric slab subject to a combination of applied voltage and axial compression, using nonlinear electro-elasticity theory and ...
Wrinkles in soft dielectric plates
(Elsevier, 2018-07-04)
We show that a smooth giant voltage actuation of soft dielectric plates is not easily obtained in practice. In principle one can exploit, through pre-deformation, the snap-through behavior of their loading curve to deliver ...