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Bi- to tetravalent glycoclusters presenting GlcNAc/GalNAc as inhibitors: from plant agglutinins to human macrophage galactose-type lectin (CD301) and galectins
(Royal Society of Chemistry, 2015-02-17)
Emerging insights into the functional spectrum of tissue lectins leads to identification of new targets for the custom-made design of potent inhibitors, providing a challenge for synthetic chemistry. The affinity and ...
Neurotrophins and B-cell malignancies
(Springer Verlag, 2015-09-23)
Neurotrophins and their receptors act as important proliferative and pro-survival factors in a variety of cell types. Neurotrophins are produced by multiple cell types in both pro and mature forms, and can act in an autocrine ...
One-pot hydrogen peroxide and hydrohalic acid induced ring closure and selective aromatic halogenation to give new ring-fused benzimidazoles
(American Chemical Society, 2015-05-19)
A new series of selectively dichlorinated and dibrominated five- to eight-membered-ring [1,2-a]-fused benzimidazoles and [1,4]oxazino[4,3-a]benzimidazoles are synthesized in mostly high yields of >80% using the reaction ...
Experimental and kinetic modeling study of the shock tube ignition of a large oxygenated fuel: tri-propylene glycol mono-methyl ether
(Elsevier, 2015-05-13)
Tri-propylene glycol monomethyl ether (TPGME) is an important oxygenated fuel additive that can be used to reduce soot in diesel engines. However, a validated chemical kinetic model that incorporates the low- to high-temperature ...
A search for pulsations from Geminga above 100 GeV with VERITAS
(American Astronomical Society, 2015-02-10)
We present the results of 71.6 hr of observations of the Geminga pulsar (PSR J0633+1746) with the VERITAS very-high-energy gamma-ray telescope array. Data taken with VERITAS between 2007 November and 2013 February were ...
The most powerful flaring activity from the NLSyl PMN J0948+0022
(Oxford University Press, 2015-01-21)
We report on multifrequency observations performed during 2012 December-2013 August of the first narrow-line Seyfert 1 galaxy detected in gamma-rays, PMN J0948+0022 (z = 0.5846). A y -ray flare was observed by the Large ...
Gamma-rays from the quasar PKS 1441+25: story of an escape
(2015-12-20)
Outbursts from gamma-ray quasars provide insights on the relativistic jets of active galactic nuclei and constraints on the diffuse radiation fields that fill the universe. The detection of significant emission above 100 ...
VERITAS observations of the BL Lac object PG 1553+113
(American Astronomical Society, 2015-01-20)
We present results from VERITAS observations of the BL Lac object PG 1553+113 spanning the years 2010, 2011, and 2012. The time-averaged spectrum, measured between 160 and 560 GeV, is well described by a power law with a ...
VLT polarimetry observations of the middle-aged pulsar PSR B0656+14
(EDP Sciences, 2015-11-02)
Context. Optical polarisation measurements are key tests for different models of the pulsar magnetosphere. Furthermore, comparing the relative orientation of the phase-averaged linear polarisation direction and the pulsar ...
Cross platform standardisation of an experimental pipeline for use in the identification of dysregulated human circulating MiRNAs
(Public Library of Science, 2015-09-10)
Micro RNAs (miRNAs) are a class of highly conserved small non-coding RNAs that play an important part in the post-transcriptional regulation of gene expression. A substantial number of miRNAs have been proposed as biomarkers ...