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Measuring the linear and nonlinear elastic properties of brain tissue with shear waves and inverse analysis

Jiang, Yi; Li, Guoyang; Qian, Lin-Xue; Liang, Si; Destrade, Michel; Cao, Yanping (Springer, 2015-02-20)

We use supersonic shear wave imaging (SSI) technique to measure not only the linear but also the nonlinear elastic properties of brain matter. Here, we tested six porcine brains ex vivo and measured the velocities of the ...

Gent models for the inflation of spherical balloons

Mangan, Robert; Destrade, Michel (Elsevier, 2015)

We revisit an iconic deformation of non-linear elasticity: the inflation of a rubber spherical thin shell. We use the 3-parameter Mooney and Gent-Gent (GG) phenomenological models to explain the stretch-strain curve of a ...

Extreme softness of brain matter in simple shear

Destrade, Michel; Murphy, J.G.; Gilchrist, M.; Rashid, J.G.; Saccomandi, Giuseppe (Elsevier, 2015-03-13)

We show that porcine brain matter can be modelled accurately as a very soft rubber-like material using the Mooney-Rivlin strain energy function, up to strains as high as 60%. This result followed from simple shear experiments ...

Incremental equations for soft fibrous materials

Destrade, Michel (Springer, 2015)

The general theory of nonlinear anisotropic elasticity is extended to describe small-amplitude motions and static deformations that can be superimposed on large pre-strains of fibre-reinforced solids. The linearised ...

Fluorescence analysis of thermoresponsive polymers

Morris, Cheryl; Ryder, Alan G. (Springer Verlag, 2015-12-18)

The use of microscale thin polymer films is widespread in biomedical science and engineering, with applications in areas such as tissue engineering, drug delivery, microfluidic devices, bio-adhesion mediators, and ...

Generation of a panel of high affinity antibodies and development of a biosensor-based immunoassay for the detection of okadaic acid in shellfish

Le Berre, Marie; Kilcoyne, Michelle; Kane, Marian (Elsevier, 2015-07-10)

Okadaic acid (OA) and its derivatives, DTX-1 and DTX-2, are marine biotoxins associated with diarrhetic shellfish poisoning. Routine monitoring of these toxins relies on the mouse bioassay. However, due to the technical ...

Functional responses and adaptation of mesophilic microbial communities to psychrophilic anaerobic digestion

Gunnigle, Eoin; Nielsen, Jeppe L.; Fuszard, Matthew; Botting, Catherine H.; Sheahan, Jerome; O'Flaherty, Vincent; Abram, Florence (Oxford University Press, 2015-10-27)

Psychrophilic (<20°C) anaerobic digestion (AD) represents an attractive alternative to mesophilic wastewater treatment. In order to investigate the AD microbiome response to temperature change, with particular emphasis on ...

Engineering a therapeutic lectin by uncoupling mitogenicity from antiviral activity

Swanson, Michael D.; Salmon, L.; Chugh, J.; Winter, H. C.; Meagher, J. L.; André, S.; Murphy, Paul V.; Oscarson, S.; Roy, R.; King, S.; Kaplan, M. H.; Goldstein, I. J.; Tarbet, E. B.; Hurst, B. L.; Smee, D. F.; de la Fuente, C.; Hoffmann, H. H.; Xue, Y.; Rice, C. M.; Schols, D.; Garcia, J. V.; Stuckey, J. A.; Gabius, H. J.; Al-Hashimi, H. M.; Markovitz, D. M.; Boudreaux, Daniel M. (Elsevier, 2015-10-22)

A key effector route of the Sugar Code involves lectins that exert crucial regulatory controls by targeting distinct cellular glycans. We demonstrate that a¿¿single amino-acid substitution in a banana lectin, replacing ...

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