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Mechanisms of ER Stress-Mediated Mitochondrial Membrane Permeabilization
(2010)
During apoptosis, the process of mitochondrial outer membrane permeabilization (MOMP) represents a point-of-no-return as it commits the cell to death. Here we have assessed the role of caspases, Bcl-2 family members and ...
Head-to-nerve analysis of electromechanical impairments of diffuse axonal injury
(Springer, 2018-11-14)
The aim was to investigate mechanical and functional failure of diffuse axonal injury (DAI) in nerve bundles following frontal head impacts, by finite element simulations. Anatomical changes following traumatic brain injury ...
Characterization of an amplified piezoelectric actuator for multiple reference optical coherence tomography
(Optica, 2018-08-30)
The characterization of an amplified piezoelectric actuator (APA) as a new axial scanning method for multiple-reference optical coherence tomography (MR-OCT) is described. MR-OCT is a compact optical imaging device based ...
Cognitive analysis of schizophrenia risk genes that function as epigenetic regulators of gene expression
(Wiley, 2016-10-20)
Epigenetic mechanisms are an important heritable and dynamic means of regulating various genomic functions, including gene expression, to orchestrate brain development, adult neurogenesis, and synaptic plasticity. These ...
Bioinformatic identification and analysis of extensins in the plant kingdom
(Public Library of Science, 2016-02-26)
Extensins (EXTs) are a family of plant cell wall hydroxyproline-rich glycoproteins (HRGPs) that are implicated to play important roles in plant growth, development, and defense. Structurally, EXTs are characterized by the ...
Population‐based identity‐by‐descent mapping combined with exome sequencing to detect rare risk variants for schizophrenia
(Wiley, 2019-02-23)
Genome‐wide association studies (GWASs) are highly effective at identifying common risk variants for schizophrenia. Rare risk variants are also important contributors to schizophrenia etiology but, with the exception of ...
Beyond the green: understanding the evolutionary puzzle of plant and algal cell walls
(American Society of Plant Biologists, 2010-04-26)
Niklas (2000) defined plants as “photosynthetic eukaryotes,” thereby including brown, red, and green macroalgae and microalgae. These groups share several features, including the presence of a complex, dynamic, and ...
Bumblebee colony development following chronic exposure to field-realistic levels of the neonicotinoid pesticide thiamethoxam under laboratory conditions
(Nature Publishing Group, 2017-08-20)
Neonicotinoid pesticides are used in agriculture to reduce damage from crop pests. However, beneficial insects such as bees can come into contact with these pesticides when foraging in treated areas, with potential ...
Quantitative polymorph contaminant analysis in tablets using Raman and near infra-red spectroscopies
(2013)
The detection and quantification of alternate polymorphs of active pharmaceutical ingredients (APIs), particularly at low concentrations is a key issue for the manufacture and analysis of solid-state formulations. Each ...
Complexifiable characteristic classes
(Springer, 2014-01)
We examine the topological characteristic cohomology classes of complexified vector bundles. In particular, all the classes coming from the real vector bundles underlying the complexification are determined.