Search
Now showing items 1-5 of 5
Coiled coil type neoglycoproteins presenting three lactose residues
(Elsevier, 2016-02-06)
Scaffold design, synthesis and application are relevant for biomedical research. For example, multivalent interactions, such as those between cell surface glycoproteins and lectins can influence the potency and duration ...
Lewis acid induced anomerization of se-glycosides. Application to synthesis of alpha-Se-GalCer
(American Chemical Society, 2016-01-22)
The TiCl4 induced anomerization of selenium glycosides of galacturonic acid derivatives is reported. The reaction was successful for galacturonic acid when various alkyl, alkenyl, alkynyl, saccharide, steroid, and lipid ...
Synthesis of an orthogonally protected polyhydroxylated cyclopentene from L-Sorbose
(Chemical Editorial Society (ACES) / Wiley, 2016-07-06)
The use of l-sorbose in the synthesis of functionalized cyclopentene derivatives was accomplished. These cyclopentene derivatives are related to those found in naturally occurring jatrophane frameworks and in other bioactive ...
Multivalent carbohydrate-lectin interactions: the way synthetic chemistry enables insights into nanometric recognition
(MDPI Open Access, 2016-05-13)
Glycan recognition by sugar receptors (lectins) is intimately involved in many aspects of cell physiology. However, the factors explaining the exquisite selectivity of their functional pairing are not yet fully understood. ...
Teaming up synthetic chemistry and histochemistry for activity screening in galectin-directed inhibitor design
(Springer, 2016-06-24)
A hallmark of endogenous lectins is their ability to select a few distinct glycoconjugates as counterreceptors for functional pairing from the natural abundance of cellular glycoproteins and glycolipids. As a consequence, ...