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Sulfamerazine: Understanding the influence of slip planes in the polymorphic phase transformation through X-ray crystallographic studies and ab initio lattice dynamics
(American Chemical Society, 2015-08-28)
Understanding the polymorphism exhibited by organic active-pharmaceutical ingredients (APIs), in particular the relationships between crystal structure and the thermodynamics of polymorph stability, is vital for the ...
Unexpected effects of catalytic amounts of additives on crystallization from the gas phase: Depression of the sublimation temperature and polymorph control
(American Chemical Society, 2016-04-11)
Sublimation of carbamazepine, piracetam, diflunisal, and p-minobenzoic acid is enhanced by the presence of additives. Temperature reductions and polymorph control have been observed. Sublimation of carbamazepine containing ...
Hydrogen bonding networks and solid-state conversions in benzamidinium salts
(2015-07-14)
Ten benzamidinium salts of carboxylic acids, amides, and sulfonamides have been crystallized from solution. Single-crystal X-ray analyses revealed various hydrogen bonding motifs which ate discussed in terms of supramolecular ...
Use of sublimation catalysis and polycrystalline powder templates for polymorph control of gas phase crystallization
(American Chemical Society, 2018-05-08)
In pursuit of a solvent-free green alternative to solution-based processes, we have applied the combined use of catalytic additives and polycrystalline powder templates for polymorph control of gas phase crystallization ...
Application of ball milling for highly selective mechanochemical polymorph transformations
(American Chemical Society, 2018-06-07)
Milling is an important secondary processing technique in the manufacture of pharmaceuticals, primarily used as a particle size reduction process. p-Aminobenzoic acid (PABA), m-aminobenzoic acid (MABA), o-aminobenzoic acid ...