Now showing items 1-5 of 5
The natural bile acid surfactant sodium taurocholate (NaTC) as a coformer in coamorphous systems: Enhanced physical stability and dissolution behavior of coamorphous drug-NaTc systems
The amorphization of 18 different drugs on milling with one mole equivalent sodium taurocholate (NaTC) was investigated. In all cases the X-ray powder pattern showed an amorphous halo after milling at room temperature or ...
Application of ball milling for highly selective mechanochemical polymorph transformations
(American Chemical Society, 2018-06-07)
Milling is an important secondary processing technique in the manufacture of pharmaceuticals, primarily used as a particle size reduction process. p-Aminobenzoic acid (PABA), m-aminobenzoic acid (MABA), o-aminobenzoic acid ...
Use of sublimation catalysis and polycrystalline powder templates for polymorph control of gas phase crystallization
(American Chemical Society, 2018-05-08)
In pursuit of a solvent-free green alternative to solution-based processes, we have applied the combined use of catalytic additives and polycrystalline powder templates for polymorph control of gas phase crystallization ...
A phosphate-targeted dinuclear Cu(II) complex combining major groove binding and oxidative DNA cleavage
(Oxford University Press, 2018-09-17)
Free radical generation is an inevitable consequence of aerobic existence and is implicated in a wide variety of pathological conditions including cancer, cardiovascular disease, ageing and neurodegenerative disorder. Free ...
Cocrystal forms of the BCS class IV drug sulfamethoxazole
(American Chemical Society, 2018-05-23)
Sulfamethoxazole, smz, is an antibiotic that is classified as a Biopharmaceutics Classification System (BCS) class IV, low solubility and low permeability drug. Cocrystal formation has been examined in an attempt to improve ...