Browsing College of Science by Author "Science Foundation Ireland"

Now showing items 1-9 of 9

    • Analyzing time-course microarray data using functional data analysis - a review 

      Coffey, Norma; Hinde, John (Statistical Applications in Genetics and Molecular Biology, 2011-05)
      Gene expression over time can be viewed as a continuous process and therefore represented as a continuous curve or function. Functional data analysis (FDA) is a statistical methodology used to analyze functional data ...

    • Dual-drug amorphous formulation of gliclazide 

      Aljohani, Marwah; McArdle, Patrick; Erxleben, Andrea (Taylor and Francis, 2021-02-01)
      Amorphization is a well-established strategy to enhance the dissolution properties of poorly water-soluble drugs. However, the amorphous state is inherently unstable toward recrystallization. Coamorphous systems of a drug ...

    • An experimental, theoretical, and modeling study of the ignition behavior of cyclopentanone 

      Zhang, Kuiwen; Lokachari, Nitin; Ninnemann, Erik; Khanniche, Sarah; Green, William H.; Curran, Henry J.; Vasu, Subith S.; Pitz, William J. (Elsevier, 2018-07-05)
      The ignition delay times of cyclopentanone in air were measured using a high pressure shock tube (HPST) and a rapid compression machine (RCM) over the temperature range of 794-1368 K at P = 15 and 30 bar and at equivalence ...

    • A hierarchical single-pulse shock tube pyrolysis study of C-2-C-6 1-alkenes 

      Nagaraja, Shashank S.; Liang, Jinhu; Dong, Shijun; Panigrahy, Snehasish; Sahu, Amrit; Kukkadapu, Goutham; Wagnon, Scott W.; Pitz, William J.; Curran, Henry J. (Elsevier, 2020-06-27)
      A single-pulse shock tube study of the pyrolysis of 2% C-2 - C-6 1-alkenes is presented at 2 bar in the tem-perature range 900-1800 K in the current study. Reactant, intermediate and product species are obtained and ...

    • Low Temperature Fluorescence Studies of Crude Petroleum Oils 

      Owens, Peter; Ryder, Alan G. (2011)
      We have studied the low-temperature (133-298 K) fluorescence emission of crude petroleum oils using a combination of steady-state and time-resolved measurements. This was done, first, to see if we could generate linear ...

    • Mechanisms of ER Stress-Mediated Mitochondrial Membrane Permeabilization 

      Gupta, Sanjeev; Cuffe, Lorraine; Szegezdi, Eva; Logue, Susan E.; Neary, Catherine; Healy, Sandra; Samali, Afshin (2010)
      During apoptosis, the process of mitochondrial outer membrane permeabilization (MOMP) represents a point-of-no-return as it commits the cell to death. Here we have assessed the role of caspases, Bcl-2 family members and ...

    • Methods for Monitoring Endoplasmic Reticulum Stress and the Unfolded Protein Response 

      Samali, Afshin; FitzGerald, Una; Deegan, Shane; Gupta, Sanjeev (2010)
      The endoplasmic reticulum (ER) is the site of folding of membrane and secreted proteins in the cell. Physiological or pathological processes that disturb protein folding in the endoplasmic reticulum cause ER stress and ...

    • Restriction of human polyomavirus BK virus DNA replication in murine cells and extracts 

      Mahon, Cathal; Tikhanovich, Irina; Nasheuer, Heinz-Peter (2009)
      BK virus (BKV) causes persistent and asymptomatic infections in most humans and is the etiologic agent of polyomavirus-associated nephropathy (PVAN) and other pathologies. Unfortunately, there are no animal models with ...

    • Synthesis of migrastatin analogues as inhibitors of tumour cell migration: Exploring structural change in and on the macrocyclic ring 

      Lo Re, Daniele; Zhou, Ying; Mucha, Joanna; Jones, Leigh F.; Leahy, Lorraine; Santocanale, Corrado; Krol, Magdalena; Murphy, Paul V. (Wiley, 2015-11-04)
      Migrastatin and isomigrastatin analogues have been synthesised in order to contribute to structure-activity studies on tumour cell migration inhibitors. These include macrocycles varying in ring size, functionality and ...