Browsing College of Science by Author "André, Sabine"
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Merging carbohydrate chemistry with lectin histochemistry to study inhibition of lectin binding by glycoclusters in the natural tissue context
André, Sabine; Kaltner, Herbert; Kayser, Klaus; Murphy, Paul V.; Gabius, Hans-Joachim (Springer, 2015-11-09)Recognition of glycans by lectins leads to cell adhesion and growth regulation. The specificity and selectivity of this process are determined by carbohydrate structure (sequence and shape) and topology of its presentation. ... -
Teaming up synthetic chemistry and histochemistry for activity screening in galectin-directed inhibitor design
Roy, René; Cao, Yihong; Kaltner, Herbert; Kottari, Naresh; Shiao, Tze Chieh; Belkhadem, Karima; André, Sabine; Manning, Joachim C.; Murphy, Paul V.; Gabius, Hans-Joachim (Springer, 2016-06-24)A hallmark of endogenous lectins is their ability to select a few distinct glycoconjugates as counterreceptors for functional pairing from the natural abundance of cellular glycoproteins and glycolipids. As a consequence, ...