Browsing College of Science by Title
Now showing items 856-875 of 970
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Synthesis of migrastatin analogues as inhibitors of tumour cell migration: exploring structural change in and on the macrocyclic ring
(Wiley, 2015-11-04)Migrastatin and isomigrastatin analogues have been synthesised in order to contribute to structure-activity studies on tumour cell migration inhibitors. These include macrocycles varying in ring size, functionality and ... -
Synthesis of migrastatin and its macroketone analogue and in vivo FRAP analysis of the macroketone on E-Cadherin dynamics
(Wiley-VCH Verlag, 2014-06-11)An efficient and scalable synthesis of a key acyclic intermediate used for the preparation of migrastatin and its macroketone analogue is described; Brown alkoxyallylation is the key step for this synthesis. The macroketone ... -
Synthesis of α-galactosyl ceramide analogues with an α-triazole at the anomeric carbon
(Elsevier, 2014-03-16)The synthesis of 1,2,3-triazole containing analogues of a-GalCer and galacturonic acid containing Sphingomonous cell wall antigens is described. Anomerisation was used to provide the required cc-glycosyl azide precursor. ... -
Synthesis, characterization and reactivity of dyad ru-based molecules for light-driven oxidation catalysis
(Wiley, 2013-03-28)Dyad molecules containing the 2,3,5,6-tetrakis(2-pyridyl)pyrazine (tppz) ligand with general formula [(tpy)Ru(μ-tppz)Ru(X)(L-L)]n+ (X=Cl, CF3COO, or H2O; L-L=2,2′-bipyridine (bpy) or 3,5-bis(2-pyridyl)pyrazole (Hbpp); ... -
Synthetic aperture Fourier holographic optical microscopy
(American Physical Society, 2006-10-18)We report a new synthetic aperture optical microscopy in which high-resolution, wide-field amplitude and phase images are synthesized from a set of Fourier holograms. Each hologram records a region of the complex two-dimensional ... -
Systems-based approaches to unravel multi-species microbial community functioning
(Research Network of Computational and Structural Biotechnology, 2014-12-03)Some of the most transformative discoveries promising to enable the resolution of this century's grand societal challenges will most likely arise from environmental science and particularly environmental microbiology ... -
The Szegö Kernel on a Sewn Riemann Surface
(2010)We describe the Szegö kernel on a higher genus Riemann surface in terms of Szegö kernel data coming from lower genus surfaces via two explicit sewing procedures where either two Riemann surfaces are sewn together or a ... -
Tailoring cocrystal and salt formation and controlling the crystal habit of diflunisal
(American Chemical Society, 2016-09-26)Crystal habit modification of the drug diflunisal that normally grows into extremely thin, long needles has been achieved by breaking the stacking effect with the help of coformers. Eight new cocrystals are reported, along ... -
Tandem reactions via Barton Esters with intermolecular addition and vinyl radical substitution onto indole
(American Chemical Society, 2014-05-16)A one-pot initiator-free Barton ester decomposition with tandem radical addition onto alkyl propiolates or phenylacetylene with aromatic substitution of the resultant vinyl radical allows convenient access to new 9-substituted ... -
Tate's and Yoshida's theorems on control of transfer for fusion systems
(2010-03)We prove analogues of results of Tate and Yoshida on control of transfer for fusion systems. This requires the notions of p-group residuals and transfer maps in cohomology for fusion systems. As a corollary, we obtain a ... -
Teaming up synthetic chemistry and histochemistry for activity screening in galectin-directed inhibitor design
(Springer, 2016-06-24)A hallmark of endogenous lectins is their ability to select a few distinct glycoconjugates as counterreceptors for functional pairing from the natural abundance of cellular glycoproteins and glycolipids. As a consequence, ... -
Tectonic structure and permeability in the Taupô Rift: new insights from analysis of LiDAR derived dems
(New Zealand Geothermal Workshop, 2017-11-22)The location of permeable zones, and preliminary quantification of a geothermal well’s production or injection capacity are routinely interpreted from well pressure, temperature, and flow measurements made at ... -
Temperature effects on brain tissue in compression
(2012)Extensive research has been carried out for at least 50 years to understand the mechanical properties of brain tissue in order to understand the mechanisms of traumatic brain injury (TBI). The observed large variability ... -
Temperature-dependent phenotypic variation of Campylobacter jejuni lipooligosaccharides
(2010-11)Background:Campylobacter jejuni is a major bacterial cause of food-borne enteritis, and its lipooligosaccharide (LOS) plays an initiating role in the development of the autoimmune neuropathy, Guillain-Barré syndrome, by ... -
Tension lines of the skin
(Springer, Cham, 2019-05-29)Skin tension lines are natural lines of tension that occur within the skin as a result of growth and remodeling mechanisms. Researchers have been aware of their existence and their surgical implications for over 150 years. ... -
Testing the validity of a mechanism describing the oxidation of binary n-heptane/toluene mixtures at engine operating conditions
(Elsevier, 2019-11-02)The aim of this work is to evaluate the influence of the n-heptane/toluene ratio on the reactivity of binary toluene reference fuels (TRFs), through a combined experimental and numerical work. Novel experimental ignition ... -
TeV and Multi-wavelength Observations of Mrk 421 in 2006-2008
(2011)We report on TeV gamma-ray observations of the blazar Mrk 421 (redshift of 0.031) with the VERITAS observatory and the Whipple 10m Cherenkov telescope. The excellent sensitivity of VERITAS allowed us to sample the TeV ... -
TeV Gamma-Ray Observations of the Perseus and Abell 2029 Galaxy Clusters
(2006)Galaxy clusters might be sources of TeV gamma rays emitted by high-energy protons and electrons accelerated by large scale structure formation shocks, galactic winds, or active galactic nuclei. Furthermore, gamma rays may ... -
Theoretical and kinetic study of the hydrogen atom abstraction reactions of esters with HO2 radicals
(American Chemical Society, 2013-10-31)This work details an ab initio and chemical kinetic study of the hydrogen atom abstraction reactions by the hydroperoxyl radical (HO2) on the following esters: methyl ethanoate, methyl propanoate, methyl butanoate, methyl ...