Corpus callosum area in patients with bipolar disorder with and without psychotic features: an international multicentre study
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2015-09-01Author
Sarrazi, Samuel
d’Albis, Marc-Antoine
McDonald, Colm
Linke, Julia
Wessa, Michèle
Phillips, Mary
Delavest, Marine
Emsell, Louise
Versace, Amelia
Almeida, Jorge
Mangin, Jean- François
Poupon, Cyril
Le Dudal, Katia
Daban, Claire
Hamdani, Nora
Leboyer, Marion
Houenou, Josselin
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Sarrazi, Samuel; d’Albis, Marc-Antoine; McDonald, Colm; Linke, Julia; Wessa, Michèle; Phillips, Mary; Delavest, Marine; Emsell, Louise; Versace, Amelia; Almeida, Jorge; Mangin, Jean- François; Poupon, Cyril; Le Dudal, Katia; Daban, Claire; Hamdani, Nora; Leboyer, Marion; Houenou, Josselin (2015). Corpus callosum area in patients with bipolar disorder with and without psychotic features: an international multicentre study. Journal of Psychiatry & Neuroscience 40 (5), 352-359
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Abstract
Background
Previous studies have reported MRI abnormalities of the corpus callosum (CC) in patients with bipolar disorder (BD), although only a few studies have directly compared callosal areas in psychotic versus nonpsychotic patients with this disorder. We sought to compare regional callosal areas in a large international multicentre sample of patients with BD and healthy controls.
Methods
We analyzed anatomic T-1 MRI data of patients with BD-I and healthy controls recruited from 4 sites (France, Germany, Ireland and the United States). We obtained the mid-sagittal areas of 7 CC subregions using an automatic CC delineation. Differences in regional callosal areas between patients and controls were compared using linear mixed models (adjusting for age, sex, handedness, brain volume, history of alcohol abuse/dependence, lithium or antipsychotic medication status, symptomatic status and site) and multiple comparisons correction. We also compared regional areas of the CC between patients with BD with and without a history of psychotic features.
Results
We included 172 patients and 146 controls in our study. Patients with BD had smaller adjusted mid-sagittal CC areas than controls along the posterior body, the isthmus and the splenium of the CC. Patients with a positive history of psychotic features had greater adjusted area of the rostral CC region than those without a history of psychotic features.
Limitations
We found small to medium effect sizes, and there was no calibration technique among the sites.
Conclusion
Our results suggest that BD with psychosis is associated with a different pattern of interhemispheric connectivity than BD without psychosis and could be considered a relevant neuroimaging subtype of BD.