Show simple item record

dc.contributor.authorSalvadore, Giacomo
dc.contributor.authorNugent, Allison C.
dc.contributor.authorChen, Guang
dc.contributor.authorAkula, Nirmala
dc.contributor.authorYuan, Peixiong
dc.contributor.authorCannon, Dara M.
dc.contributor.authorZarate, Carlos A.
dc.contributor.authorMcMahon, Francis J.
dc.contributor.authorManji, Husseini K.
dc.contributor.authorDrevets, Wayne C.
dc.date.accessioned2018-09-20T16:23:47Z
dc.date.available2018-09-20T16:23:47Z
dc.date.issued2009-10-01
dc.identifier.citationSalvadore, Giacomo; Nugent, Allison C. Chen, Guang; Akula, Nirmala; Yuan, Peixiong; Cannon, Dara M.; Zarate, Carlos A.; McMahon, Francis J.; Manji, Husseini K.; Drevets, Wayne C. (2009). Bcl-2 polymorphism influences gray matter volume in the ventral striatum in healthy humans. Biological Psychiatry 66 (8), 804-807
dc.identifier.issn0006-3223
dc.identifier.urihttp://hdl.handle.net/10379/13782
dc.description.abstractBackground: Bcl-2 is a major regulator of neural plasticity and cellular resilience. A single nucleotide polymorphism (SNP) in the Bcl-2 gene, Bcl-2 rs956572, significantly modulates the expression of Bcl-2 protein and cellular vulnerability to apoptosis. We tested the hypothesis that this SNP would modulate gray matter (GM) volume in the limbic-cortical-striatal-pallidal-thalamic circuitry that plays major roles in mood regulation. Methods: Forty-seven healthy subjects participated in this study (30 A carriers, 17 G homozygotes). Neuromorphometric differences between G homozygotes and A carriers were investigated using optimized voxel-based morphometry (VBM). Statistical significance was set at p<.05, corrected for multiple comparisons. Results: A carriers showed less GM volume than G homozygotes in the left ventral striatum (p(corrected)<.05). Conclusions: Genetic variation in the Bcl-2 gene modulates GM volume in areas known to play key roles in the neurobiology of reward processes and emotion regulation and in the pathophysiology of mood disorders. Thus, the findings from the current study are noteworthy insofar as they converge with preclinical findings that Bcl-2 functions to enhance neuronal viability and might indirectly extend this evidence to humans.
dc.publisherElsevier BV
dc.relation.ispartofBiological Psychiatry
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/ie/
dc.subjectaccumbens
dc.subjectmagnetic resonance imaging
dc.subjectneurogenetics
dc.subjectneuroplasticity
dc.subjectvoxel-based morphometry (vbm)
dc.subjectmood disorders
dc.subjecthuman brain
dc.subjectdepression
dc.subjectresilience
dc.subjectexpression
dc.subjectlithium
dc.subjectgene
dc.titleBcl-2 polymorphism influences gray matter volume in the ventral striatum in healthy humans
dc.typeArticle
dc.identifier.doi10.1016/j.biopsych.2009.05.025
dc.local.publishedsourcehttp://europepmc.org/articles/pmc2788985?pdf=render
nui.item.downloads0


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivs 3.0 Ireland
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Ireland