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dc.contributor.authorRusling, James F.
dc.contributor.authorKumar, Challa V.
dc.contributor.authorGutkind, J. Silvio
dc.contributor.authorPatel, Vyomesh
dc.identifier.citationRusling, James F. Kumar, Challa V.; Gutkind, J. Silvio; Patel, Vyomesh (2010). Measurement of biomarker proteins for point-of-care early detection and monitoring of cancer. The Analyst 135 (10), 2496-2511
dc.description.abstractThis critical review evaluates progress toward viable point-of-care protein biomarker measurements for cancer detection and diagnostics. The ability to measure panels of specific, selective cancer biomarker proteins in physicians' surgeries and clinics has the potential to revolutionize cancer detection, monitoring, and therapy. The dream envisions reliable, cheap, automated, technically undemanding devices that can analyze a patient's serum or saliva in a clinical setting, allowing on-the-spot diagnosis. Existing commercial products for protein assays are reliable in laboratory settings, but have limitations for point-of-care applications. A number of ultrasensitive immunosensors and some arrays have been developed, many based on nanotechnology. Multilabel detection coupled with high capture molecule density in immunosensors and arrays seems to be capable of detecting a wide range of protein concentrations with sensitivity ranging into the sub pg mL(-1) level. Multilabel arrays can be designed to detect both high and ultralow abundance proteins in the same sample. However, only a few of the newer ultrasensitive methods have been evaluated with real patient samples, which is key to establishing clinical sensitivity and selectivity.
dc.publisherRoyal Society of Chemistry (RSC)
dc.relation.ispartofThe Analyst
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.subjectsurface-plasmon resonance
dc.subjectrolling-circle amplification
dc.subjectprostate-specific antigen
dc.subjectsquamous-cell carcinoma
dc.subjectcarbon nanotube forest
dc.subjectelectrochemical detection
dc.subjectproteomic analysis
dc.subjectantibody arrays
dc.titleMeasurement of biomarker proteins for point-of-care early detection and monitoring of cancer

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Attribution-NonCommercial-NoDerivs 3.0 Ireland
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Ireland