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dc.contributor.authorRoy, René
dc.contributor.authorMurphy, Paul
dc.contributor.authorGabius, Hans-Joachim
dc.date.accessioned2018-09-20T16:23:18Z
dc.date.available2018-09-20T16:23:18Z
dc.date.issued2016-05-13
dc.identifier.citationRoy, René; Murphy, Paul; Gabius, Hans-Joachim (2016). Multivalent carbohydrate-lectin interactions: how synthetic chemistry enables insights into nanometric recognition. Molecules 21 (5),
dc.identifier.issn1420-3049
dc.identifier.urihttp://hdl.handle.net/10379/13714
dc.description.abstractGlycan recognition by sugar receptors (lectins) is intimately involved in many aspects of cell physiology. However, the factors explaining the exquisite selectivity of their functional pairing are not yet fully understood. Studies toward this aim will also help appraise the potential for lectin-directed drug design. With the network of adhesion/growth-regulatory galectins as therapeutic targets, the strategy to recruit synthetic chemistry to systematically elucidate structure-activity relationships is outlined, from monovalent compounds to glyco-clusters and glycodendrimers to biomimetic surfaces. The versatility of the synthetic procedures enables to take examining structural and spatial parameters, alone and in combination, to its limits, for example with the aim to produce inhibitors for distinct galectin(s) that exhibit minimal reactivity to other members of this group. Shaping spatial architectures similar to glycoconjugate aggregates, microdomains or vesicles provides attractive tools to disclose the often still hidden significance of nanometric aspects of the different modes of lectin design (sequence divergence at the lectin site, differences of spatial type of lectin-site presentation). Of note, testing the effectors alone or in combination simulating (patho) physiological conditions, is sure to bring about new insights into the cooperation between lectins and the regulation of their activity.
dc.publisherMDPI AG
dc.relation.ispartofMolecules
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/ie/
dc.subjectagglutinin
dc.subjectgalectin
dc.subjectglycocluster
dc.subjectglycodendrimer
dc.subjectglycophane
dc.subjectglycoprotein
dc.subjectliposomes
dc.subjectoligosaccharides
dc.subjectsugar code
dc.subjectadhesion/growth-regulatory galectins
dc.subjectmedically relevant lectins
dc.subjectdefined janus glycodendrimers
dc.subjectpancreatic-carcinoma model
dc.subjectsugar code
dc.subjectglycan microarrays
dc.subjectanimal lectins
dc.subjecthigh-affinity
dc.subjectcell-surface
dc.subjecttetravalent glycoclusters
dc.titleMultivalent carbohydrate-lectin interactions: how synthetic chemistry enables insights into nanometric recognition
dc.typeArticle
dc.identifier.doi10.3390/molecules21050629
dc.local.publishedsourcehttp://www.mdpi.com/1420-3049/21/5/629/pdf
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Attribution-NonCommercial-NoDerivs 3.0 Ireland
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Ireland