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Biological insights from 108 schizophrenia-associated genetic loci

dc.contributor.authorRipke, Stephan
dc.contributor.authorNeale, Benjamin M.
dc.contributor.authorCorvin, Aiden
dc.contributor.authorWalters, James T. R.
dc.contributor.authorFarh, Kai-How
dc.contributor.authorHolmans, Peter A.
dc.contributor.authorLee, Phil
dc.contributor.authorBulik-Sullivan, Brendan
dc.contributor.authorCollier, David A.
dc.contributor.authorHuang, Hailiang
dc.contributor.authorPers, Tune H.
dc.contributor.authorAgartz, Ingrid
dc.contributor.authorAgerbo, Esben
dc.contributor.authorAlbus, Margot
dc.contributor.authorAlexander, Madeline
dc.contributor.authorAmin, Farooq
dc.contributor.authorBacanu, Silviu A.
dc.contributor.authorBegemann, Martin
dc.contributor.authorBelliveau Jr, Richard A.
dc.contributor.authorBene, Judit
dc.contributor.authorBergen, Sarah E.
dc.contributor.authorBevilacqua, Elizabeth
dc.contributor.authorBigdeli, Tim B.
dc.contributor.authorBlack, Donald W.
dc.contributor.authorBruggeman, Richard
dc.contributor.authorBuccola, Nancy G.
dc.contributor.authorBuckner, Randy L.
dc.contributor.authorByerley, William
dc.contributor.authorCahn, Wiepke
dc.contributor.authorCai, Guiqing
dc.contributor.authorCampion, Dominique
dc.contributor.authorCantor, Rita M.
dc.contributor.authorCarr, Vaughan J.
dc.contributor.authorCarrera, Noa
dc.contributor.authorCatts, Stanley V.
dc.contributor.authorChambert, Kimberly D.
dc.contributor.authorChan, Raymond C. K.
dc.contributor.authorChen, Ronald Y. L.
dc.contributor.authorChen, Eric Y. H.
dc.contributor.authorCheng, Wei
dc.contributor.authorCheung, Eric F. C.
dc.contributor.authorAnn Chong, Siow
dc.contributor.authorRobert Cloninger, C.
dc.contributor.authorCohen, David
dc.contributor.authorCohen, Nadine
dc.contributor.authorCormican, Paul
dc.contributor.authorCraddock, Nick
dc.contributor.authorCrowley, James J.
dc.contributor.authorCurtis, David
dc.contributor.authorDavidson, Michael
dc.contributor.authorDavis, Kenneth L.
dc.contributor.authorDegenhardt, Franziska
dc.contributor.authorDel Favero, Jurgen
dc.contributor.authorDemontis, Ditte
dc.contributor.authorDikeos, Dimitris
dc.contributor.authorDinan, Timothy
dc.contributor.authorDjurovic, Srdjan
dc.contributor.authorDonohoe, Gary
dc.contributor.authorDrapeau, Elodie
dc.contributor.authorDuan, Jubao
dc.contributor.authorDudbridge, Frank
dc.contributor.authorDurmishi, Naser
dc.contributor.authorEichhammer, Peter
dc.contributor.authorEriksson, Johan
dc.contributor.authorEscott-Price, Valentina
dc.contributor.authorEssioux, Laurent
dc.contributor.authorFanous, Ayman H.
dc.contributor.authorFarrell, Martilias S.
dc.contributor.authorFrank, Josef
dc.contributor.authorFranke, Lude
dc.contributor.authorFreedman, Robert
dc.contributor.authorFreimer, Nelson B.
dc.contributor.authorFriedl, Marion
dc.contributor.authorFriedman, Joseph I.
dc.contributor.authorFromer, Menachem
dc.contributor.authorGenovese, Giulio
dc.contributor.authorGeorgieva, Lyudmila
dc.contributor.authorGiegling, Ina
dc.contributor.authorGiusti-Rodríguez, Paola
dc.contributor.authorGodard, Stephanie
dc.contributor.authorGoldstein, Jacqueline I.
dc.contributor.authorGolimbet, Vera
dc.contributor.authorGopal, Srihari
dc.contributor.authorGratten, Jacob
dc.contributor.authorde Haan, Lieuwe
dc.contributor.authorHammer, Christian
dc.contributor.authorHamshere, Marian L.
dc.contributor.authorHansen, Mark
dc.contributor.authorHansen, Thomas
dc.contributor.authorHaroutunian, Vahram
dc.contributor.authorHartmann, Annette M.
dc.contributor.authorHenskens, Frans A.
dc.contributor.authorHerms, Stefan
dc.contributor.authorHirschhorn, Joel N.
dc.contributor.authorHoffmann, Per
dc.contributor.authorHofman, Andrea
dc.contributor.authorHollegaard, Mads V.
dc.contributor.authorHougaard, David M.
dc.contributor.authorIkeda, Masashi
dc.contributor.authorJoa, Inge
dc.contributor.authorJulià, Antonio
dc.contributor.authorKahn, René S.
dc.contributor.authorKalaydjieva, Luba
dc.contributor.authorKarachanak-Yankova, Sena
dc.contributor.authorKarjalainen, Juha
dc.contributor.authorKavanagh, David
dc.contributor.authorKeller, Matthew C.
dc.contributor.authorKennedy, James L.
dc.contributor.authorKhrunin, Andrey
dc.contributor.authorKim, Yunjung
dc.contributor.authorKlovins, Janis
dc.contributor.authorKnowles, James A.
dc.contributor.authorKonte, Bettina
dc.contributor.authorKucinskas, Vaidutis
dc.contributor.authorAusrele Kucinskiene, Zita
dc.contributor.authorKuzelova-Ptackova, Hana
dc.contributor.authorKähler, Anna K.
dc.contributor.authorLaurent, Claudine
dc.contributor.authorLee Chee Keong, Jimmy
dc.contributor.authorHong Lee, S.
dc.contributor.authorLegge, Sophie E.
dc.contributor.authorLerer, Bernard
dc.contributor.authorLi, Miaoxin
dc.contributor.authorLi, Tao
dc.contributor.authorLiang, Kung-Yee
dc.contributor.authorLieberman, Jeffrey
dc.contributor.authorLimborska, Svetlana
dc.contributor.authorLoughland, Carmel M.
dc.contributor.authorLubinski, Jan
dc.contributor.authorLönnqvist, Jouko
dc.contributor.authorMacek Jr, Milan
dc.contributor.authorMagnusson, Patrik K. E.
dc.contributor.authorMaher, Brion S.
dc.contributor.authorMaier, Wolfgang
dc.contributor.authorMallet, Jacques
dc.contributor.authorMarsal, Sara
dc.contributor.authorMattheisen, Manuel
dc.contributor.authorMattingsdal, Morten
dc.contributor.authorMcCarley, Robert W.
dc.contributor.authorMcDonald, Colm
dc.contributor.authorMcIntosh, Andrew M.
dc.contributor.authorMeier, Sandra
dc.contributor.authorMeijer, Carin J.
dc.contributor.authorMelegh, Bela
dc.contributor.authorMelle, Ingrid
dc.contributor.authorMesholam-Gately, Raquelle I.
dc.contributor.authorMetspalu, Andres
dc.contributor.authorMichie, Patricia T.
dc.contributor.authorMilani, Lili
dc.contributor.authorMilanova, Vihra
dc.contributor.authorMokrab, Younes
dc.contributor.authorMorris, Derek W.
dc.contributor.authorMors, Ole
dc.contributor.authorMurphy, Kieran C.
dc.contributor.authorMurray, Robin M.
dc.contributor.authorMyin-Germeys, Inez
dc.contributor.authorMüller-Myhsok, Bertram
dc.contributor.authorNelis, Mari
dc.contributor.authorNenadic, Igor
dc.contributor.authorNertney, Deborah A.
dc.contributor.authorNestadt, Gerald
dc.contributor.authorNicodemus, Kristin K.
dc.contributor.authorNikitina-Zake, Liene
dc.contributor.authorNisenbaum, Laura
dc.contributor.authorNordin, Annelie
dc.contributor.authorO’Callaghan, Eadbhard
dc.contributor.authorO’Dushlaine, Colm
dc.contributor.authorO’Neill, F. Anthony
dc.contributor.authorOh, Sang-Yun
dc.contributor.authorOlincy, Ann
dc.contributor.authorOlsen, Line
dc.contributor.authorVan Os, Jim
dc.contributor.authorEndophenotypes International Consortium, Psychosis
dc.contributor.authorPantelis, Christos
dc.contributor.authorPapadimitriou, George N.
dc.contributor.authorPapiol, Sergi
dc.contributor.authorParkhomenko, Elena
dc.contributor.authorPato, Michele T.
dc.contributor.authorPaunio, Tiina
dc.contributor.authorPejovic-Milovancevic, Milica
dc.contributor.authorPerkins, Diana O.
dc.contributor.authorPietiläinen, Olli
dc.contributor.authorPimm, Jonathan
dc.contributor.authorPocklington, Andrew J.
dc.contributor.authorPowell, John
dc.contributor.authorPrice, Alkes
dc.contributor.authorPulver, Ann E.
dc.contributor.authorPurcell, Shaun M.
dc.contributor.authorQuested, Digby
dc.contributor.authorRasmussen, Henrik B.
dc.contributor.authorReichenberg, Abraham
dc.contributor.authorReimers, Mark A.
dc.contributor.authorRichards, Alexander L.
dc.contributor.authorRoffman, Joshua L.
dc.contributor.authorRoussos, Panos
dc.contributor.authorRuderfer, Douglas M.
dc.contributor.authorSalomaa, Veikko
dc.contributor.authorSanders, Alan R.
dc.contributor.authorSchall, Ulrich
dc.contributor.authorSchubert, Christian R.
dc.contributor.authorSchulze, Thomas G.
dc.contributor.authorSchwab, Sibylle G.
dc.contributor.authorScolnick, Edward M.
dc.contributor.authorScott, Rodney J.
dc.contributor.authorSeidman, Larry J.
dc.contributor.authorShi, Jianxin
dc.contributor.authorSigurdsson, Engilbert
dc.contributor.authorSilagadze, Teimuraz
dc.contributor.authorSilverman, Jeremy M.
dc.contributor.authorSim, Kang
dc.contributor.authorSlominsky, Petr
dc.contributor.authorSmoller, Jordan W.
dc.contributor.authorSo, Hon-Cheong
dc.contributor.authorSpencer, ChrisC. A.
dc.contributor.authorStahl, Eli A.
dc.contributor.authorStefansson, Hreinn
dc.contributor.authorSteinberg, Stacy
dc.contributor.authorStogmann, Elisabeth
dc.contributor.authorStraub, Richard E.
dc.contributor.authorStrengman, Eric
dc.contributor.authorStrohmaier, Jana
dc.contributor.authorScott Stroup, T.
dc.contributor.authorSubramaniam, Mythily
dc.contributor.authorSuvisaari, Jaana
dc.contributor.authorSvrakic, Dragan M.
dc.contributor.authorSzatkiewicz, Jin P.
dc.contributor.authorSöderman, Erik
dc.contributor.authorThirumalai, Srinivas
dc.contributor.authorToncheva, Draga
dc.contributor.authorTosato, Sarah
dc.contributor.authorVeijola, Juha
dc.contributor.authorWaddington, John
dc.contributor.authorWalsh, Dermot
dc.contributor.authorWang, Dai
dc.contributor.authorWang, Qiang
dc.contributor.authorWebb, Bradley T.
dc.contributor.authorWeiser, Mark
dc.contributor.authorWildenauer, Dieter B.
dc.contributor.authorWilliams, Nigel M.
dc.contributor.authorWilliams, Stephanie
dc.contributor.authorWitt, Stephanie H.
dc.contributor.authorWolen, Aaron R.
dc.contributor.authorWong, Emily H. M.
dc.contributor.authorWormley, Brandon K.
dc.contributor.authorSimon Xi, Hualin
dc.contributor.authorZai, Clement C.
dc.contributor.authorZheng, Xuebin
dc.contributor.authorZimprich, Fritz
dc.contributor.authorWray, Naomi R.
dc.contributor.authorStefansson, Kari
dc.contributor.authorVisscher, Peter M.
dc.contributor.authorTrust Case-Control Consortium, Wellcome
dc.contributor.authorAdolfsson, Rolf
dc.contributor.authorAndreassen, Ole A.
dc.contributor.authorBlackwood, Douglas H. R.
dc.contributor.authorBramon, Elvira
dc.contributor.authorBuxbaum, Joseph D.
dc.contributor.authorBørglum, Anders D.
dc.contributor.authorCichon, Sven
dc.contributor.authorDarvasi, Ariel
dc.contributor.authorDomenici, Enrico
dc.contributor.authorEhrenreich, Hannelore
dc.contributor.authorEsko, Tõnu
dc.contributor.authorGejman, Pablo V.
dc.contributor.authorGill, Michael
dc.contributor.authorGurling, Hugh
dc.contributor.authorHultman, Christina M.
dc.contributor.authorIwata, Nakao
dc.contributor.authorJablensky, Assen V.
dc.contributor.authorJönsson, Erik G.
dc.contributor.authorKendler, Kenneth S.
dc.contributor.authorKirov, George
dc.contributor.authorKnight, Jo
dc.contributor.authorLencz, Todd
dc.contributor.authorLevinson, Douglas F.
dc.contributor.authorLi, Qingqin S.
dc.contributor.authorLiu, Jianjun
dc.contributor.authorMalhotra, Anil K.
dc.contributor.authorMcCarroll, Steven A.
dc.contributor.authorMcQuillin, Andrew
dc.contributor.authorMoran, Jennifer L.
dc.contributor.authorMortensen, Preben B.
dc.contributor.authorMowry, Bryan J.
dc.contributor.authorNöthen, Markus M.
dc.contributor.authorOphoff, Roel A.
dc.contributor.authorOwen, Michael J.
dc.contributor.authorPalotie, Aarno
dc.contributor.authorPato, Carlos N.
dc.contributor.authorPetryshen, Tracey L.
dc.contributor.authorPosthuma, Danielle
dc.contributor.authorRietschel, Marcella
dc.contributor.authorRiley, Brien P.
dc.contributor.authorRujescu, Dan
dc.contributor.authorSham, Pak C.
dc.contributor.authorSklar, Pamela
dc.contributor.authorSt Clair, David
dc.contributor.authorWeinberger, Daniel R.
dc.contributor.authorWendland, Jens R.
dc.contributor.authorWerge, Thomas
dc.contributor.authorDaly, Mark J.
dc.contributor.authorSullivan, Patrick F.
dc.contributor.authorO’Donovan, Michael C.
dc.date.accessioned2018-09-20T16:22:54Z
dc.date.available2018-09-20T16:22:54Z
dc.date.issued2014-07-22
dc.identifier.citationRipke, Stephan; Neale, Benjamin M. Corvin, Aiden; Walters, James T. R.; Farh, Kai-How; Holmans, Peter A.; Lee, Phil; Bulik-Sullivan, Brendan; Collier, David A.; Huang, Hailiang; Pers, Tune H.; Agartz, Ingrid; Agerbo, Esben; Albus, Margot; Alexander, Madeline; Amin, Farooq; Bacanu, Silviu A.; Begemann, Martin; Belliveau Jr, Richard A.; Bene, Judit; Bergen, Sarah E.; Bevilacqua, Elizabeth; Bigdeli, Tim B.; Black, Donald W.; Bruggeman, Richard; Buccola, Nancy G.; Buckner, Randy L.; Byerley, William; Cahn, Wiepke; Cai, Guiqing; Campion, Dominique; Cantor, Rita M.; Carr, Vaughan J.; Carrera, Noa; Catts, Stanley V.; Chambert, Kimberly D.; Chan, Raymond C. K.; Chen, Ronald Y. L.; Chen, Eric Y. H.; Cheng, Wei; Cheung, Eric F. C.; Ann Chong, Siow; Robert Cloninger, C.; Cohen, David; Cohen, Nadine; Cormican, Paul; Craddock, Nick; Crowley, James J.; Curtis, David; Davidson, Michael; Davis, Kenneth L.; Degenhardt, Franziska; Del Favero, Jurgen; Demontis, Ditte; Dikeos, Dimitris; Dinan, Timothy; Djurovic, Srdjan; Donohoe, Gary; Drapeau, Elodie; Duan, Jubao; Dudbridge, Frank; Durmishi, Naser; Eichhammer, Peter; Eriksson, Johan; Escott-Price, Valentina; Essioux, Laurent; Fanous, Ayman H.; Farrell, Martilias S.; Frank, Josef; Franke, Lude; Freedman, Robert; Freimer, Nelson B.; Friedl, Marion; Friedman, Joseph I.; Fromer, Menachem; Genovese, Giulio; Georgieva, Lyudmila; Giegling, Ina; Giusti-Rodríguez, Paola; Godard, Stephanie; Goldstein, Jacqueline I.; Golimbet, Vera; Gopal, Srihari; Gratten, Jacob; de Haan, Lieuwe; Hammer, Christian; Hamshere, Marian L.; Hansen, Mark; Hansen, Thomas; Haroutunian, Vahram; Hartmann, Annette M.; Henskens, Frans A.; Herms, Stefan; Hirschhorn, Joel N.; Hoffmann, Per; Hofman, Andrea; Hollegaard, Mads V.; Hougaard, David M.; Ikeda, Masashi; Joa, Inge; Julià, Antonio; Kahn, René S.; Kalaydjieva, Luba; Karachanak-Yankova, Sena; Karjalainen, Juha; Kavanagh, David; Keller, Matthew C.; Kennedy, James L.; Khrunin, Andrey; Kim, Yunjung; Klovins, Janis; Knowles, James A.; Konte, Bettina; Kucinskas, Vaidutis; Ausrele Kucinskiene, Zita; Kuzelova-Ptackova, Hana; Kähler, Anna K.; Laurent, Claudine; Lee Chee Keong, Jimmy; Hong Lee, S.; Legge, Sophie E.; Lerer, Bernard; Li, Miaoxin; Li, Tao; Liang, Kung-Yee; Lieberman, Jeffrey; Limborska, Svetlana; Loughland, Carmel M.; Lubinski, Jan; Lönnqvist, Jouko; Macek Jr, Milan; Magnusson, Patrik K. E.; Maher, Brion S.; Maier, Wolfgang; Mallet, Jacques; Marsal, Sara; Mattheisen, Manuel; Mattingsdal, Morten; McCarley, Robert W.; McDonald, Colm; McIntosh, Andrew M.; Meier, Sandra; Meijer, Carin J.; Melegh, Bela; Melle, Ingrid; Mesholam-Gately, Raquelle I.; Metspalu, Andres; Michie, Patricia T.; Milani, Lili; Milanova, Vihra; Mokrab, Younes; Morris, Derek W.; Mors, Ole; Murphy, Kieran C.; Murray, Robin M.; Myin-Germeys, Inez; Müller-Myhsok, Bertram; Nelis, Mari; Nenadic, Igor; Nertney, Deborah A.; Nestadt, Gerald; Nicodemus, Kristin K.; Nikitina-Zake, Liene; Nisenbaum, Laura; Nordin, Annelie; O’Callaghan, Eadbhard; O’Dushlaine, Colm; O’Neill, F. Anthony; Oh, Sang-Yun; Olincy, Ann; Olsen, Line; Van Os, Jim; Endophenotypes International Consortium, Psychosis; Pantelis, Christos; Papadimitriou, George N.; Papiol, Sergi; Parkhomenko, Elena; Pato, Michele T.; Paunio, Tiina; Pejovic-Milovancevic, Milica; Perkins, Diana O.; Pietiläinen, Olli; Pimm, Jonathan; Pocklington, Andrew J.; Powell, John; Price, Alkes; Pulver, Ann E.; Purcell, Shaun M.; Quested, Digby; Rasmussen, Henrik B.; Reichenberg, Abraham; Reimers, Mark A.; Richards, Alexander L.; Roffman, Joshua L.; Roussos, Panos; Ruderfer, Douglas M.; Salomaa, Veikko; Sanders, Alan R.; Schall, Ulrich; Schubert, Christian R.; Schulze, Thomas G.; Schwab, Sibylle G.; Scolnick, Edward M.; Scott, Rodney J.; Seidman, Larry J.; Shi, Jianxin; Sigurdsson, Engilbert; Silagadze, Teimuraz; Silverman, Jeremy M.; Sim, Kang; Slominsky, Petr; Smoller, Jordan W.; So, Hon-Cheong; Spencer, ChrisC. A.; Stahl, Eli A.; Stefansson, Hreinn; Steinberg, Stacy; Stogmann, Elisabeth; Straub, Richard E.; Strengman, Eric; Strohmaier, Jana; Scott Stroup, T.; Subramaniam, Mythily; Suvisaari, Jaana; Svrakic, Dragan M.; Szatkiewicz, Jin P.; Söderman, Erik; Thirumalai, Srinivas; Toncheva, Draga; Tosato, Sarah; Veijola, Juha; Waddington, John; Walsh, Dermot; Wang, Dai; Wang, Qiang; Webb, Bradley T.; Weiser, Mark; Wildenauer, Dieter B.; Williams, Nigel M.; Williams, Stephanie; Witt, Stephanie H.; Wolen, Aaron R.; Wong, Emily H. M.; Wormley, Brandon K.; Simon Xi, Hualin; Zai, Clement C.; Zheng, Xuebin; Zimprich, Fritz; Wray, Naomi R.; Stefansson, Kari; Visscher, Peter M.; Trust Case-Control Consortium, Wellcome; Adolfsson, Rolf; Andreassen, Ole A.; Blackwood, Douglas H. R.; Bramon, Elvira; Buxbaum, Joseph D.; Børglum, Anders D.; Cichon, Sven; Darvasi, Ariel; Domenici, Enrico; Ehrenreich, Hannelore; Esko, Tõnu; Gejman, Pablo V.; Gill, Michael; Gurling, Hugh; Hultman, Christina M.; Iwata, Nakao; Jablensky, Assen V.; Jönsson, Erik G.; Kendler, Kenneth S.; Kirov, George; Knight, Jo; Lencz, Todd; Levinson, Douglas F.; Li, Qingqin S.; Liu, Jianjun; Malhotra, Anil K.; McCarroll, Steven A.; McQuillin, Andrew; Moran, Jennifer L.; Mortensen, Preben B.; Mowry, Bryan J.; Nöthen, Markus M.; Ophoff, Roel A.; Owen, Michael J.; Palotie, Aarno; Pato, Carlos N.; Petryshen, Tracey L.; Posthuma, Danielle; Rietschel, Marcella; Riley, Brien P.; Rujescu, Dan; Sham, Pak C.; Sklar, Pamela; St Clair, David; Weinberger, Daniel R.; Wendland, Jens R.; Werge, Thomas; Daly, Mark J.; Sullivan, Patrick F.; O’Donovan, Michael C. (2014). Biological insights from 108 schizophrenia-associated genetic loci. Nature 511 (7510),
dc.identifier.issn0028-0836,1476-4687
dc.identifier.urihttp://hdl.handle.net/10379/13659
dc.description.abstractSchizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association studies. Here we report a multi-stage schizophrenia genome-wide association study of up to 36,989 cases and 113,075 controls. We identify 128 independent associations spanning 108 conservatively defined loci that meet genome-wide significance, 83 of which have not been previously reported. Associations were enriched among genes expressed in brain, providing biological plausibility for the findings. Many findings have the potential to provide entirely new insights into aetiology, but associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses. Independent of genes expressed in brain, associations were enriched among genes expressed in tissues that have important roles in immunity, providing support for the speculated link between the immune system and schizophrenia.
dc.publisherSpringer Nature
dc.relation.ispartofNature
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/ie/
dc.subjectgenome-wide association
dc.subjectcommon variants
dc.subjectbipolar disorder
dc.subjectconferring risk
dc.subjectdisease
dc.subjectmetaanalysis
dc.subjectmutations
dc.subjectdrugs
dc.titleBiological insights from 108 schizophrenia-associated genetic loci
dc.typeArticle
dc.identifier.doi10.1038/nature13595
dc.local.publishedsourcehttp://www.nature.com/nature/journal/v511/n7510/pdf/nature13595.pdf
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